Bone disorders exact a considerable toll on human health in both children and adults. Dr. Long seeks to understand the fundamental mechanisms underlying both normal skeletal development and the pathophysiology of bone diseases. His current research includes studies of skeletal stem cells and progenitors, metabolic regulation of bone cells, and the integration of bone and whole-body metabolism.
Dr. Katz’s investigates the sequelae of obesity and type 2 diabetes mellitus in youth. Her research involves the intersection of sleep, obesity, and glucose intolerance and prevention of cardiovascular risk. Her studies have led to the evaluation of quantitative tools important for assessment of metabolic risk in youth.
In the lab of Paula Oliver, PhD, associate professor of Pathology at Children’s Hospital of Philadelphia, a group of researchers led by Awo Layman, PhD; Guoping Deng, PhD; and Claire O’Leary, PhD, studied the influential events that transpire when, as Dr. Layman described it to us, a type of immune cell called a regulatory T cell suffers a “loss of identity.”
Fitness tools that monitor your daily use of energy, from counting steps to tracking sleep, have exploded in popularity. Researchers are developing better noninvasive, high-resolution methods to estimate how well the fundamental source of that energy - your mitochondria - are working, and they have recently had some important successes. Mitochondria are the tiny energy factories of our cells,
Bookended by references to the 1980s and 1990s — in the form of an iconic U.S. Navy commercial and a discussion of the 1991 measles outbreak in Philadelphia — the 2015 CHOP Research Institute Scientific Symposium offered a snapshot of the inspirational work going on at CHOP every day.