Welcome back to another weekly roundup of research news from the Children's Hospital of Philadelphia! Exciting and important pediatric research spans everything from conditions that are common and treatable, such as ear infections, to others more rare and deadly, such as cancer.
Many autoimmune diseases run in families, and because individual patients often have more than one autoimmune condition, clinicians have long suspected that these disorders have shared genetic predispositions.
Genes provide tremendous information about how our bodies work and our possible predisposition for a variety of diseases and conditions. Researchers are working to discern what specific genes and gene regions play a role in disease. The Children's Hospital of Philadelphia played a major role in a recent international genetics study that found four new gene regions that contribute to low
The Gadue Laboratory studies human pancreatic and hematopoietic development and associated diseases using human pluripotent stem cells, including embryonic stem cells and induced pluripotent stem cells. The lab has devoted much of its research efforts on directed differentiation and CRISPR-based genome engineering of stem cells and is using this system for the study and development of treatments for diabetes and blood disorders.