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Results for Gene Regulation

1 - 10 of 163

Peter S. Choi, PhD
Peter S. Choi Headshot

Dr. Choi's research focuses on the role of RNA-binding proteins in the regulation of alternative splicing and how mutations in these factors contribute to cancer. He uses a combination of genetically-engineered models and high-throughput approaches to better understand how alternative splicing influences cellular function and to identify potential opportunities for therapeutic intervention.

E-mail:
choip [at] chop.edu
Kai Tan, PhD
Kai Tan

Dr. Tan studies transcriptional regulation during normal development and disease. This involves the interplay of multiple transcription and epigenetic factors in a 3D chromosomal environment. Using experimental genomics and computational modeling, Dr. Tan investigates transcriptional regulatory networks underlying embryonic hematopoiesis, T cell differentiation, and pediatric leukemia.

E-mail:
tank1 [at] chop.edu
Lindsey A. George, MD
Lindsey A. George

Dr. George's basic and clinical research interests are in the development of novel therapeutics for hemophilia. Her basic science laboratory studies the molecular basis of coagulation, and she is the principal investigator of ongoing hemophilia A and B gene therapy trials.

E-mail:
georgel [at] chop.edu
Christopher J. Cardinale, MD, PhD
Christopher J. Cardinale

Dr. Cardinale's research is focused on understanding the mechanisms of gene expression and gene regulation in autoimmune diseases, including inflammatory bowel disease, type 1 diabetes, and systemic sclerosis. He uses data from large-scale genomic studies to identify disease-causing genetic variants and functionally explore the target genes of those variants.

E-mail:
cardinalec [at] chop.edu
Andrew D. Wells, PhD
Andrew D. Wells

Dr. Wells studies the genetic, epigenetic, and transcriptional mechanisms that control T lymphocyte immunity and tolerance.

E-mail:
wellsa [at] chop.edu
Craig H. Bassing, PhD
Craig H. Bassing

Dr. Bassing's research program focuses on the genetic, epigenetic, and biochemical mechanisms by which mammals develop their immune systems while suppressing autoimmunity and genomic aberrations that cause leukemia or lymphoma.

E-mail:
bassing [at] chop.edu
Lan Lin, PhD
Lan Lin

Dr. Lin studies RNA modifications (a.k.a "epitranscriptomics") in human diseases, including cancer. She develops and applies high-throughput sequencing strategies and transcriptome engineering technologies to study the regulation and function of RNA modifications, including A-to-I RNA editing and m6A RNA methylation.

E-mail:
linlan [at] chop.edu
Louis R. Ghanem, MD, PhD
Louis R. Ghanem, MD, PhD

Dr. Ghanem investigates the impact of transcriptional gene expression controls and mRNA processing upon the severity and progression of pediatric inflammatory bowel disease.

E-mail:
ghaneml [at] chop.edu
Michael S. Marks, PhD
Michael S. Marks

Dr. Marks investigates the molecular mechanisms underlying the formation of cell type-specific lysosome-related organelles; the assembly, delivery and function of their contents; and how these processes are impacted by genetic diseases.

E-mail:
marksms [at] chop.edu
Rodney M. Camire, PhD
Rodney M. Camire Headshot

Dr. Camire's research focuses on understanding the components of the blood coagulation system, how they interface with activated cells, and how disturbances in their function lead to bleeding and thrombosis. He is also interested in developing novel therapeutic approaches (protein, gene-based, small molecule) to mitigate these events, which are major causes of morbidity and mortality worldwide.

E-mail:
camire [at] chop.edu
1 - 10 of 163

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In this section

Filter By

  • Principal Investigator / Faculty (17)
  • Researcher / Lab Personnel (1)

Organizations

  • Center for Applied Genomics (14)
  • Raymond G. Perelman Center for Cellular and Molecular Therapeutics (14)
  • Center for Computational and Genomic Medicine (13)
  • Department of Pathology and Laboratory Medicine (13)
  • Department of Pediatrics (11)
  • Center for Autism Research (8)
  • Center for Mitochondrial and Epigenomic Medicine (7)
  • Division of Allergy and Immunology (7)
  • Center for Childhood Cancer Research (6)
  • Center for Injury Research and Prevention (6)
  • Division of Gastroenterology, Hepatology, and Nutrition (6)
  • Division of Oncology (6)
  • PolicyLab (5)
  • Spatial and Functional Genomics Collaborative (5)
  • Center for Pediatric Clinical Effectiveness (4)
  • Division of Hematology (4)
  • Division of Human Genetics (4)
  • Division of Infectious Diseases (4)
  • Division of Neonatology (4)
  • Department of Anesthesiology and Critical Care Medicine (3)
  • Department of Biomedical and Health Informatics (3)
  • Division of Endocrinology and Diabetes (3)
  • Division of Neurology (3)
  • Lifespan Brain Institute (3)
  • Office of Academic Training and Outreach Programs (3)
  • PennCHOP Microbiome Program (3)
  • Roberts Individualized Medical Genetics Center (3)
  • Akizu Laboratory (2)
  • Bernt Laboratory (2)
  • Blobel Laboratory (2)
  • Davidson Laboratory (2)
  • Department of Child and Adolescent Psychiatry and Behavioral Sciences (2)
  • Division of Cancer Pathobiology (2)
  • Food Allergy Center (2)
  • Grant Laboratory (2)
  • Lurie Family Foundations MEG Imaging Center (2)
  • Mir Laboratory (2)
  • Mitochondrial Medicine (2)
  • Spatial and Functional Genomics Research Affinity Group (2)
  • Wells Laboratory (2)
  • Bailis Laboratory (1)
  • Cancer Immunotherapy (CAR-T) (1)
  • Center for Applied Genomics Laboratory (1)
  • Center for Child Injury Prevention Studies (1)
  • Center for Data-Driven Discovery in Biomedicine (1)
  • Center for the Investigation of Factor FVIII Immunogenicity (1)
  • Children’s Oncology Group (1)
  • Choi Laboratory (1)
  • Comprehensive Bone Marrow Failure Center (1)
  • Comprehensive Center for the Cure of Sickle Cell Disease and Other Red Blood Cell Disorders (1)
  • Department of Radiology (1)
  • Department of Surgery (1)
  • Division of Cardiology (1)
  • Division of Neurosurgery (1)
  • Division of Plastic and Reconstructive Surgery (1)
  • Division of Pulmonary and Sleep Medicine (1)
  • Division of Rheumatology (1)
  • Division of Transplant Immunology (1)
  • Hamilton Laboratory (1)
  • Inflammatory Bowel Disease Center (1)
  • Intellectual and Developmental Disabilities Research Center (1)
  • Jill and Mark Fishman Center for Lymphatic Disorders (1)
  • Kurre Laboratory (1)
  • Leukodystrophy Center of Excellence (1)
  • Lin Laboratory (1)
  • Maris Laboratory (1)
  • Marks Laboratory (1)
  • Mitchell Laboratory (1)
  • Pennsylvania Pediatric Medical Device Consortium (1)
  • Rivella Laboratory (1)
  • Shalem Laboratory (1)
  • St. Geme Laboratory (1)
  • Stress Neurobiology Program (1)
  • Thomas-Tikhonenko Laboratory (1)
  • Translational Research Program in Pediatric Orthopaedics (1)

In this section

Filter By

  • Principal Investigator / Faculty (17)
  • Researcher / Lab Personnel (1)

Organizations

  • Center for Applied Genomics (14)
  • Raymond G. Perelman Center for Cellular and Molecular Therapeutics (14)
  • Center for Computational and Genomic Medicine (13)
  • Department of Pathology and Laboratory Medicine (13)
  • Department of Pediatrics (11)
  • Center for Autism Research (8)
  • Center for Mitochondrial and Epigenomic Medicine (7)
  • Division of Allergy and Immunology (7)
  • Center for Childhood Cancer Research (6)
  • Center for Injury Research and Prevention (6)
  • Division of Gastroenterology, Hepatology, and Nutrition (6)
  • Division of Oncology (6)
  • PolicyLab (5)
  • Spatial and Functional Genomics Collaborative (5)
  • Center for Pediatric Clinical Effectiveness (4)
  • Division of Hematology (4)
  • Division of Human Genetics (4)
  • Division of Infectious Diseases (4)
  • Division of Neonatology (4)
  • Department of Anesthesiology and Critical Care Medicine (3)
  • Department of Biomedical and Health Informatics (3)
  • Division of Endocrinology and Diabetes (3)
  • Division of Neurology (3)
  • Lifespan Brain Institute (3)
  • Office of Academic Training and Outreach Programs (3)
  • PennCHOP Microbiome Program (3)
  • Roberts Individualized Medical Genetics Center (3)
  • Akizu Laboratory (2)
  • Bernt Laboratory (2)
  • Blobel Laboratory (2)
  • Davidson Laboratory (2)
  • Department of Child and Adolescent Psychiatry and Behavioral Sciences (2)
  • Division of Cancer Pathobiology (2)
  • Food Allergy Center (2)
  • Grant Laboratory (2)
  • Lurie Family Foundations MEG Imaging Center (2)
  • Mir Laboratory (2)
  • Mitochondrial Medicine (2)
  • Spatial and Functional Genomics Research Affinity Group (2)
  • Wells Laboratory (2)
  • Bailis Laboratory (1)
  • Cancer Immunotherapy (CAR-T) (1)
  • Center for Applied Genomics Laboratory (1)
  • Center for Child Injury Prevention Studies (1)
  • Center for Data-Driven Discovery in Biomedicine (1)
  • Center for the Investigation of Factor FVIII Immunogenicity (1)
  • Children’s Oncology Group (1)
  • Choi Laboratory (1)
  • Comprehensive Bone Marrow Failure Center (1)
  • Comprehensive Center for the Cure of Sickle Cell Disease and Other Red Blood Cell Disorders (1)
  • Department of Radiology (1)
  • Department of Surgery (1)
  • Division of Cardiology (1)
  • Division of Neurosurgery (1)
  • Division of Plastic and Reconstructive Surgery (1)
  • Division of Pulmonary and Sleep Medicine (1)
  • Division of Rheumatology (1)
  • Division of Transplant Immunology (1)
  • Hamilton Laboratory (1)
  • Inflammatory Bowel Disease Center (1)
  • Intellectual and Developmental Disabilities Research Center (1)
  • Jill and Mark Fishman Center for Lymphatic Disorders (1)
  • Kurre Laboratory (1)
  • Leukodystrophy Center of Excellence (1)
  • Lin Laboratory (1)
  • Maris Laboratory (1)
  • Marks Laboratory (1)
  • Mitchell Laboratory (1)
  • Pennsylvania Pediatric Medical Device Consortium (1)
  • Rivella Laboratory (1)
  • Shalem Laboratory (1)
  • St. Geme Laboratory (1)
  • Stress Neurobiology Program (1)
  • Thomas-Tikhonenko Laboratory (1)
  • Translational Research Program in Pediatric Orthopaedics (1)
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