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Results for Gene Editing

1 - 10 of 103

Lan Lin, PhD
Lan Lin

Dr. Lin studies RNA modifications (a.k.a "epitranscriptomics") in human diseases, including cancer. She develops and applies high-throughput sequencing strategies and transcriptome engineering technologies to study the regulation and function of RNA modifications, including A-to-I RNA editing and m6A RNA methylation.

E-mail:
linlan [at] chop.edu
Beverly L. Davidson, PhD
Photo of Beverly L. Davidson, PhD

Dr. Davidson works to understand the molecular basis of childhood onset neurodegenerative diseases and the development of gene and small molecule therapies for treatment. She also focuses on how noncoding RNAs participate in neural development and neurodegenerative disease processes, and how they can be harnessed for therapies.

E-mail:
davidsonbl [at] chop.edu
Deborah L. French, PhD
Deborah French

Dr. French came to CHOP in 2008 to establish the Human Pluripotent Stem Cell Core in the Center for Cellular and Molecular Therapeutics. She is an internationally recognized researcher involved in multi-investigator teams that utilize pluripotent stem cells for modeling human disease to study mechanism, development, and establish new therapeutic modalities.

E-mail:
frenchd [at] chop.edu
Christopher J. Cardinale, MD, PhD
Christopher J. Cardinale

Dr. Cardinale's research is focused on understanding the mechanisms of gene expression and gene regulation in autoimmune diseases, including inflammatory bowel disease, type 1 diabetes, and systemic sclerosis. He uses data from large-scale genomic studies to identify disease-causing genetic variants and functionally explore the target genes of those variants.

E-mail:
cardinalec [at] chop.edu
Evan Weber, PhD
Evan W. Weber

Dr. Weber is developing approaches to enhance CAR-T cell therapies for pediatric cancer by reprogramming T cells with improved durability and exhaustion resistance. His work will uncover molecular mechanisms that promote CAR-T cell exhaustion and identify new targets for therapeutic intervention.

E-mail:
weberew [at] chop.edu
Amanda M. Ackermann, MD, PhD
Amanda M. Ackermann

Dr. Ackermann studies diabetes (types 1 and 2) and congenital hyperinsulinism using mouse models, cell lines, and primary human tissue. She aims to identify novel pathways regulating beta cell insulin secretion, leading to innovative therapeutic strategies for these disorders. Current studies include in vivo mouse physiology, ex vivo human islet physiology, CRISPR-Cas9 gene editing, epigenetic modification, and single-cell functional genomics.

E-mail:
ackermanna [at] chop.edu
Peter S. Choi, PhD
Peter S. Choi Headshot

Dr. Choi's research focuses on the role of RNA-binding proteins in the regulation of alternative splicing and how mutations in these factors contribute to cancer. He uses a combination of genetically-engineered models and high-throughput approaches to better understand how alternative splicing influences cellular function and to identify potential opportunities for therapeutic intervention.

E-mail:
choip [at] chop.edu
Will Bailis, PhD
Will Bailis

Dr. Bailis aims to understand how metabolism underlies immunology and disease, by controlling the biochemistry of cells and tissues. His lab does so using in vitro and in vivo CRISPR engineering of primary human and mouse immune cells, with the goal of developing diet and metabolite based therapies.

E-mail:
bailisw [at] chop.edu

From ‘Generation to Generation:’ Faculty Spotlight With Itzhak Nissim, PhD

Published on
Apr 27, 2022
in Cornerstone Blog
Faculty Spotlight With Itzhak Nissim, PhD
Dr. Nissim studies the relationship of the metabolome and the fluxome to the genome in normal and disease states.

In The News: March of Dimes Prize, Immunotherapy, CHOP CARES, MIS-C, PCORI Grant

Published on
Feb 4, 2022
in Cornerstone Blog
In the News
Learn about novel findings neuroblastoma, MIS-C, and more in this week's roundup of research news.
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In this section

Filter By

  • Principal Investigator / Faculty (8)
  • Research Administration (1)

Organizations

  • Center for Injury Research and Prevention (19)
  • Raymond G. Perelman Center for Cellular and Molecular Therapeutics (19)
  • Center for Autism Research (13)
  • PolicyLab (13)
  • Center for Childhood Cancer Research (12)
  • Department of Pediatrics (9)
  • Center for Applied Genomics (8)
  • Department of Pathology and Laboratory Medicine (8)
  • Division of Hematology (7)
  • Division of Oncology (7)
  • Center for Computational and Genomic Medicine (6)
  • Center for Pediatric Clinical Effectiveness (6)
  • Department of Biomedical and Health Informatics (6)
  • Division of Allergy and Immunology (6)
  • Department of Anesthesiology and Critical Care Medicine (5)
  • Mitochondrial Medicine (5)
  • Office of Academic Training and Outreach Programs (5)
  • Roberts Individualized Medical Genetics Center (5)
  • Center for Mitochondrial and Epigenomic Medicine (4)
  • Division of Human Genetics (4)
  • Division of Infectious Diseases (4)
  • Division of Neurology (4)
  • Division of Cancer Pathobiology (3)
  • Division of Pulmonary and Sleep Medicine (3)
  • PennCHOP Microbiome Program (3)
  • Cancer Immunotherapy (CAR-T) (2)
  • Center for Child Injury Prevention Studies (2)
  • Center for Data-Driven Discovery in Biomedicine (2)
  • Children’s Oncology Group (2)
  • Department of Child and Adolescent Psychiatry (2)
  • Division of Emergency Medicine (2)
  • Division of Endocrinology and Diabetes (2)
  • Division of Gastroenterology, Hepatology, and Nutrition (2)
  • Division of Neonatology (2)
  • Lifespan Brain Institute (2)
  • PEDSnet (2)
  • Spatial and Functional Genomics Collaborative (2)
  • Blobel Laboratory (1)
  • Cell and Gene Therapy Collaborative (1)
  • Center for Applied Genomics Laboratory (1)
  • Center for Human Phenomic Science (1)
  • CHOP Microbiome Center (1)
  • Clinical Vector Core (1)
  • Cystic Fibrosis-Related Diabetes Research Program (1)
  • Department of Radiology (1)
  • Department of Surgery (1)
  • Division of Adolescent Medicine (1)
  • Division of Cardiology (1)
  • Division of Nephrology (1)
  • Division of Neurosurgery (1)
  • Division of Ophthalmology (1)
  • Division of Orthopaedic Surgery (1)
  • Division of Plastic and Reconstructive Surgery (1)
  • Division of Urology (1)
  • Epilepsy NeuroGenetics Initiative (ENGIN) (1)
  • Fetal Biology and Therapy Research Affinity Group (1)
  • Grant Laboratory (1)
  • Human Pluripotent Stem Cell Core (1)
  • Nissim Laboratory (1)
  • Office of Faculty Development (1)
  • Pennsylvania Pediatric Medical Device Consortium (1)
  • Research Vector Core (1)
  • Romberg Laboratory (1)
  • Shalem Laboratory (1)
  • Stress Neurobiology Program (1)
  • Thomas-Tikhonenko Laboratory (1)
  • Translational Research Program in Pediatric Orthopaedics (1)
  • Wells Laboratory (1)
  • Wyss/Campbell Center for Thoracic Insufficiency Syndrome (1)

In this section

Filter By

  • Principal Investigator / Faculty (8)
  • Research Administration (1)

Organizations

  • Center for Injury Research and Prevention (19)
  • Raymond G. Perelman Center for Cellular and Molecular Therapeutics (19)
  • Center for Autism Research (13)
  • PolicyLab (13)
  • Center for Childhood Cancer Research (12)
  • Department of Pediatrics (9)
  • Center for Applied Genomics (8)
  • Department of Pathology and Laboratory Medicine (8)
  • Division of Hematology (7)
  • Division of Oncology (7)
  • Center for Computational and Genomic Medicine (6)
  • Center for Pediatric Clinical Effectiveness (6)
  • Department of Biomedical and Health Informatics (6)
  • Division of Allergy and Immunology (6)
  • Department of Anesthesiology and Critical Care Medicine (5)
  • Mitochondrial Medicine (5)
  • Office of Academic Training and Outreach Programs (5)
  • Roberts Individualized Medical Genetics Center (5)
  • Center for Mitochondrial and Epigenomic Medicine (4)
  • Division of Human Genetics (4)
  • Division of Infectious Diseases (4)
  • Division of Neurology (4)
  • Division of Cancer Pathobiology (3)
  • Division of Pulmonary and Sleep Medicine (3)
  • PennCHOP Microbiome Program (3)
  • Cancer Immunotherapy (CAR-T) (2)
  • Center for Child Injury Prevention Studies (2)
  • Center for Data-Driven Discovery in Biomedicine (2)
  • Children’s Oncology Group (2)
  • Department of Child and Adolescent Psychiatry (2)
  • Division of Emergency Medicine (2)
  • Division of Endocrinology and Diabetes (2)
  • Division of Gastroenterology, Hepatology, and Nutrition (2)
  • Division of Neonatology (2)
  • Lifespan Brain Institute (2)
  • PEDSnet (2)
  • Spatial and Functional Genomics Collaborative (2)
  • Blobel Laboratory (1)
  • Cell and Gene Therapy Collaborative (1)
  • Center for Applied Genomics Laboratory (1)
  • Center for Human Phenomic Science (1)
  • CHOP Microbiome Center (1)
  • Clinical Vector Core (1)
  • Cystic Fibrosis-Related Diabetes Research Program (1)
  • Department of Radiology (1)
  • Department of Surgery (1)
  • Division of Adolescent Medicine (1)
  • Division of Cardiology (1)
  • Division of Nephrology (1)
  • Division of Neurosurgery (1)
  • Division of Ophthalmology (1)
  • Division of Orthopaedic Surgery (1)
  • Division of Plastic and Reconstructive Surgery (1)
  • Division of Urology (1)
  • Epilepsy NeuroGenetics Initiative (ENGIN) (1)
  • Fetal Biology and Therapy Research Affinity Group (1)
  • Grant Laboratory (1)
  • Human Pluripotent Stem Cell Core (1)
  • Nissim Laboratory (1)
  • Office of Faculty Development (1)
  • Pennsylvania Pediatric Medical Device Consortium (1)
  • Research Vector Core (1)
  • Romberg Laboratory (1)
  • Shalem Laboratory (1)
  • Stress Neurobiology Program (1)
  • Thomas-Tikhonenko Laboratory (1)
  • Translational Research Program in Pediatric Orthopaedics (1)
  • Wells Laboratory (1)
  • Wyss/Campbell Center for Thoracic Insufficiency Syndrome (1)
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