Dr. Zhou’s outstanding research interests include mitosis-coupled DNA methylation drift and inference of cell-type-specific epigenetic signals. He developed multiple computational tools for analyzing DNA methylation data and has actively contributed to cancer genomics data analysis.
The 2014 Penn Medicine Awards of Excellence recognize faculty from The Perelman School of Medicine who exemplify the highest values of innovation, commitment to service, leadership, dedication to patient care, and scholarship and teaching.
The Computational Epigenetics Lab develops novel algorithms and big data analytics to understand epigenetic cell identity and its dynamics in cell fate transition, organismal development, and human disease. The team disentangles cellular and physiological processes that impact DNA methylation and chromatin states.
The Blobel Lab investigates the fundamental mechanisms involving transcription factors, chromatin regulators, and higher order chromatin, gearing its basic science discoveries toward genetic and epigenetic treatment modalities.
The Lefebvre Lab advances the understanding of skeletal and neurodevelopmental syndromes. To this end, the team is decrypting mechanisms controlling the identity and activities of stem cells and differentiated cells governing these processes.