Results for Eosinophilic Esophagitis

Dr. Spergel focuses on translational research in IgE-mediated and non-IgE-mediated food allergy, examining novel clinical methods for desensitization and curing food allergy. His other main projects are to identify predictive factors for severity of reactions using molecular, physiologic, and clinical parameters.

Dr. Ruchelli is an attending pathologist with the Congenital Hyperinsulinism Center and the Division of Anatomic Pathology at CHOP, and an associate professor of pathology and laboratory medicine at the University of Penn. His research focuses on congenital hyperinsulinism and eosinophilic esophagitis.

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Dr. Muir investigates the mechanisms underlying esophageal fibrosis to improve therapeutic and diagnostic approaches.

Dr. Merves has a background in basic and clinical translational research in eosinophilic esophagitis. Her more recent focus is clinical research in the pediatric short-bowel population. Dr. Merves is currently evaluating blenderized feeding in the pediatric short bowel population.

Classic food allergies are mediated through immunoglobulin E and manifest as hives, vomiting, and anaphylaxis. Dr. Ruffner investigates the immune mechanisms of food allergy disorders which are not mediated through immunoglobulin E. In particular, the mechanisms of eosinophilic esophagitis and food-protein induced enterocolitis syndrome are of particular interest in Dr. Ruffner's laboratory.

Dr. Benitez is currently building a comprehensive translational research program in which he hopes to study the role of brain-gut-microbiome and microbiome-mucosal interactions in the development of functional GI and motility disorders.

Dr. Grant uses high-throughput genotyping and sequencing technologies, combined with statistical and bioinformatic approaches, to unravel genomic puzzles related to multiple common complex traits.

Dr. Hill seeks to understand how the immune system contributes to the two most common chronic diseases of childhood: allergy and obesity. He uses clinical and epidemiological information to guide basic and translational research on the genetic, epigenetic, and immunologic basis of these important conditions.