Results for Directed Differentiation

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Véronique Lefebvre, PhD
Véronique Lefebvre

Dr. Lefebvre investigates the genetic mechanisms that generate the diversity of cell types composing the body. Her emphasis is on deciphering how proteins called SOX transcription factors specify stem cells and highly specialized cells in the skeleton, how changes in these factors cause skeletal diseases, and how these factors also control other processes, including brain development and intellectual disability diseases.

E-mail:
lefebvrev1 [at] email.chop.edu
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Adda Grimberg, MD
Adda Grimberg

Dr. Grimberg investigates the growth hormone (GH)/insulin-like growth factor (IGF)-I axis and clinical issues related to child growth. Her recent research is focused on disparities in, and the decision-making related to, the medical management of children with short stature. She is fascinated by how differential societal pressures for tallness and the advent of an expensive therapeutic have transformed a fundamental aspect of pediatric healthcare.

E-mail:
grimberg [at] email.chop.edu
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Biomedical Optical Devices to Monitor Cerebral Health

Published on
Feb 18, 2020
in Cornerstone Blog
Biomedical Optical Devices to Monitor Cerebral Health Frontier Program
An optical device could revolutionize cardiac resuscitation by providing real-time feedback to the person performing CPR.

Putting the Brakes on Allergic Response

Published on
Apr 21, 2016
in Cornerstone Blog
When you have a chronic allergic disorder, it’s easy to blame the trigger — an early pollen season or furry pet — but the real culprit is your own immune system. Designed to attack foreign substances such as bacteria and viruses, T cells are the immune system’s watchdog to recognize serious threats. But sometimes T cells can be too zealous and set in motion a signaling cascade that can cause allergic reactions to everyday things and even attack your body’s healthy cells by mistake.

Treating the Chicken with the Egg

Published on
Jan 28, 2014
in Cornerstone Blog
The term “stem cell,” stammzellen, was first used in 1868 by the German biologist Ernst Haeckel to describe the original, unicellular progenitor from which Dr. Haekel supposed all multicellular plant and animal life might have descended.

Turning Stem Cells into Brain Cells Sheds Light on Neural Development

Published on
May 15, 2013
in Cornerstone Blog
Stem cells have the unique ability to develop, or differentiate, into other kinds of cells in the body. Researchers have now manipulated human stem cells so that they produce the types of brain cells that play important roles in neurodevelopmental disorders such as epilepsy, schizophrenia, and autism.

Human Pluripotent Stem Cell Core

The Human Pluripotent Stem Cell Core provides services for the development of novel, human cell-based experimental models for elucidating the pathophysiology of genetic disorders.

Gadue Laboratory

Gadue Lab

The Gadue Laboratory studies human pancreatic and hematopoietic development and associated diseases using human pluripotent stem cells, including embryonic stem cells and induced pluripotent stem cells. The lab has devoted much of its research efforts on directed differentiation and CRISPR-based genome engineering of stem cells and is using this system for the study and development of treatments for diabetes and blood disorders.

Marks Laboratory

Marks Lab

The Marks Lab aims to dissect the molecular mechanisms underlying the formation of cell type-specific lysosome-related organelles and the assembly, delivery, and function of their contents, and to understand how these processes are impacted by genetic diseases. The lab focuses on processes of importance to the pigmentary, immune, and hemostasis systems, with broad application to understanding organelle biogenesis, signaling, and function within the endolysosomal system.

Long Laboratory

Long Laboratory

The research focus in the Long Lab centers on understanding how the mammalian skeleton is formed and maintained in a functional state throughout life.

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