A pediatric cardiologist at The Children’s Hospital of Philadelphia is a first author of new research identifying a mutation that disrupts the formation of veins bringing blood to the heart very early in development. The abnormal connections and blood flow result in so-called “blue babies” — newborns with a potentially deadly heart condition.
The Gadue Laboratory studies human pancreatic and hematopoietic development and associated diseases using human pluripotent stem cells, including embryonic stem cells and induced pluripotent stem cells. The lab has devoted much of its research efforts on directed differentiation and CRISPR-based genome engineering of stem cells and is using this system for the study and development of treatments for diabetes and blood disorders.
The long-term goal of the Song Lab is to elucidate the cellular and molecular basis governing the formation, maintenance, and function of neural circuits under physiological and pathological conditions, using both Drosophila and mammalian models