Focusing on the underpinnings of progressive insulin secretion defects and worsening glucose tolerance in children and adults with cystic fibrosis, and examining the links between hyperglycemia and insulin deficiency and cystic fibrosis-related outcomes.
The purpose of this research study is to examine and understand the various mechanisms that contribute to Cystic Fibrosis Related Diabetes and gain a better understanding of potential means to treat Cystic Fibrosis Related Diabetes.
The goal of the study extension is to see whether the incretin hormone GIP increases insulin secretion in individuals with CF and normal glucose tolerance compared to individuals without CF and normal glucose tolerance.
Dr. Jennifer Bouso is a 3rd year Pulmonary fellow at Children's Hospital of Philadelphia. Her research focuses on understanding in-host evolution of nontuberculous mycobacteria (NTM) in patients with cystic fibrosis (CF).