Dr. Tan studies transcriptional regulation during normal development and disease. This involves the interplay of multiple transcription and epigenetic factors in a 3D chromosomal environment. Using experimental genomics and computational modeling, Dr. Tan investigates transcriptional regulatory networks underlying embryonic hematopoiesis, T cell differentiation, and pediatric leukemia.
Dr. Tunç is a computational scientist investigating the application of machine learning and statistical data analysis in various domains such as digital phenotyping, nature of psychopathology, and neuroimaging. He participates in studies using normative, developmental, and clinical samples to parse heterogeneity in psychiatric disorders by developing novel computational techniques.
Dr. Jolley's research lab is focused on visualizing and quantifying congenitally abnormal heart structures using 3D imaging with the driving goal of informing surgical and interventional planning in children and adults with congenital heart disease.
Dr. Sgourakis’ research focuses on understanding the intricate molecular mechanisms that determine the vast repertoire of peptide antigens displayed by the proteins of the Major Histocompatibility Complex for immune surveillance by T cells and Natural Killer cells.
Dr. Pasha studies the mechanism of spinal deformity development in the pediatric population. She uses analytical and computational methods to better understand the pathogenesis of pediatric scoliosis. Her lab develops medical devices and software packages that can be used in orthopedic clinics worldwide.
Dr. Alexander-Bloch investigates normal brain development and the altered developmental trajectories that lead to mental illness. His multi-disciplinary research integrates brain imaging, genomics and clinical information.