Dr. Tan studies transcriptional regulation during normal development and disease. This involves the interplay of multiple transcription and epigenetic factors in a 3D chromosomal environment. Using experimental genomics and computational modeling, Dr. Tan investigates transcriptional regulatory networks underlying embryonic hematopoiesis, T cell differentiation, and pediatric leukemia.
Dr. Diskin's research is focused on translational genomics in childhood cancers. Her laboratory seeks to identify the genetic basis of childhood cancers by combining quantitative computational methods with rigorous "wet-lab" experimental approaches. In parallel, she has developed, and is applying, a proteogenomic approach to identify novel immunotherapeutic targets for high-risk and relapsed pediatric malignancies.
Whitney Guthrie, PhD, is a clinical psychologist and scientist at the Center for Autism Research. Dr. Guthrie’s research focuses on the early developmental trajectories that characterize autism spectrum disorder with the ultimate goal of improving early detection and intervention.
Dr. Pasha studies the mechanism of spinal deformity development in the pediatric population. She uses analytical and computational methods to better understand the pathogenesis of pediatric scoliosis. Her lab develops medical devices and software packages that can be used in orthopedic clinics worldwide.
Dr. Sgourakis’ research focuses on understanding the intricate molecular mechanisms that determine the vast repertoire of peptide antigens displayed by the proteins of the Major Histocompatibility Complex for immune surveillance by T cells and Natural Killer cells.
Dr. Alexander-Bloch investigates normal brain development and the altered developmental trajectories that lead to mental illness. His multi-disciplinary research integrates brain imaging, genomics and clinical information.