Dr. Hamilton studies intestinal epithelial cells and how they help maintain human health. Although there is a great deal understood about how these cells function, little is known about how they behave during disease. Dr. Hamilton focuses on defining new mechanisms in regenerative medicine, inflammatory bowel disease, and colorectal cancer.
Dr. MacFarland's research focuses on syndromes that predispose to cancer development in children and adolescents. She has initiated several individual and collaborative research projects, working in pediatric polyposis syndromes and Li-Fraumeni syndrome. She is uncovering novel genomic drivers of disease and identifying biomarkers of cancer onset and progression.
Dr. Zackular's research is focused on understanding how interactions between the host, gut microbiota, and pathogenic microbes impact human health and disease. His recent efforts center on understanding how the important nosocomial pathogen, Clostridium difficile, interacts with resident gut microbiota during infection and how interspecies cross-talk impacts growth, behavior, and virulence of this pathogen.
Vice President Joe Biden’s ambitious “Moonshot” initiative is aimed at boosting and streamlining cancer research across the country. We asked Andrei Thomas-Tikhonenko, PhD, chief of the Division of Cancer Pathobiology and an investigator for the Center for Childhood Cancer Research at The Children’s Hospital of Philadelphia, to share his thoughts on how this strategic plan is changing the landscape of pediatric cancer research.
At the 13th Annual Dream & Promise Gala, set to be held tonight in New York, the Children’s Brain Tumor Foundation will honor Tom Curran, PhD, FRS, with the 2015 Fred J. Epstein, MD, Lifetime Achievement Award.
Two recent awards to CHOP researchers show the incredible breadth of research being conducted at The Children's Hospital of Philadelphia Research Institute every day. Supported by the Pennsylvania Department of Health's Commonwealth Universal Research Enhancement program, Struan Grant, Phd, will lead an investigation of the genetic links between type 2 diabetes and cancer, while Jennifer F. Culhane, PhD, will study developmental-behavioral screening instruments in children.
The Hamilton Lab studies epithelial cells in the intestine and colon and the roles they play in maintaining human health. Because there is still much to learn about how these cells behave during stress and disease, the lab is working to identify new mechanisms directly relevant to regenerative medicine, inflammatory bowel disease, and colorectal cancer