Results for Chromatin Regulators

1 - 10 of 18

Dr. Deardorff’s work integrates patient information with genomics and cell biology to diagnosis and understand rare genetic disease. His research focuses on disorders caused by dysregulation of chromatin or altered translational regulation, specifically, Cornelia de Lange, Coffin-Siris, Skraban-Deardorff and KBG syndromes.

E-mail:

deardorff [at] email.chop.edu

View Matthew A. Deardorff 's Profile

Gerd Blobel, MD, PhD

Dr. Blobel investigates the fundamental mechanisms involving transcription factors, chromatin regulators, and higher order chromatin. He is gearing his basic science discoveries towards genetic and epigenetic treatment modalities. In addition, Dr. Blobel is interested in mechanism of epigenetic memory.

E-mail:

blobel [at] email.chop.edu

View Gerd Blobel's Profile

Kathrin M. Bernt, MD

As a physician-scientist, Dr. Bernt's goal is to further the understanding of the role of transcriptional regulation in pediatric hematopoietic stem cell biology and leukemia, and translate findings into novel therapies.

E-mail:

berntk [at] email.chop.edu

View Kathrin M. Bernt's Profile

Andrew D. Wells, PhD

Dr. Wells studies the genetic, epigenetic, and transcriptional mechanisms that control T lymphocyte immunity and tolerance.

E-mail:

wellsa [at] email.chop.edu

View Andrew D. Wells's Profile

Research Implicates Causative Genes in Osteoporosis, Suggesting New Targets for Future Therapy

Published on

Mar 21, 2019

in Press Releases

Scientists have harnessed powerful data analysis tools and three-dimensional studies of genomic geography to implicate new risk genes for osteoporosis, the chronic bone-weakening condition that affects millions of people. Knowing the causative genes may later open the door to more effective treatments.

Different Walks of Life: Q&A With Annabel Torres, PhD, New Diversity Fellow

Published on

Feb 21, 2018

in Cornerstone Blog

Meet Annabel Torres, PhD, one of our newest Diversity Fellows at Children's Hospital of Philadelphia.

Scientists Reveal New Mechanism Adenovirus Uses to Sabotage Immune System

Published on

Jun 30, 2016

in Cornerstone Blog

Adenovirus, a common human virus that usually affects the lungs and causes respiratory tract infections, is an old friend to virologists. They have long studied how this virus interacts with host cells to understand cellular processes and reveal key regulators of cellular functions.

Possible 'Central Hub' Proteins Found in Cancer Cell Growth

Published on

Dec 16, 2015

in Cornerstone Blog

A study from researchers at The Children’s Hospital of Philadelphia may add new lines to the textbook description of how cancer cells divide uncontrollably and develop into tumors.

Gene-regulating Protein Reaches Multiple Disease Pathways

Published on

Nov 14, 2014

in Cornerstone Blog

Genomic scientists at The Children’s Hospital of Philadelphia found strong evidence that the protein family, FOXA2, is a master regulator of genetically vulnerable pathways in multiple diseases.

Forced Looping Viable Strategy to Reverse Globin Switch

Published on

Aug 15, 2014

in Cornerstone Blog

Investigators at The Children’s Hospital of Philadelphia are exploring a new gene therapy approach that aims to reactivate the production of fetal hemoglobin as a potential intervention for patients with sickle cell disease.