Results for Chromatin Disorders

Share:
1 - 10 of 10
Matthew A. Deardorff , MD, PhD
Photo of Matthew A. Deardorff

Dr. Deardorff’s work integrates patient information with genomics and cell biology to diagnosis and understand rare genetic disease.  His research focuses on disorders caused by dysregulation of chromatin or altered translational regulation, specifically, Cornelia de Lange, Coffin-Siris, Skraban-Deardorff and KBG syndromes.

E-mail:
deardorff [at] chop.edu

In the News: Mitochondrial Disease, ALL, Type 2 Diabetes, Sleep Apnea

Published on
Sep 16, 2022
in Cornerstone Blog
In the News
This week’s In the News highlights research on mitochondrial disease, acute lymphoblastic leukemia, type 2 diabetes, and sleep apnea.

In The News: STAT Madness, Autistic Adolescents, Invasive Candidiasis, Allergen Label Warnings, ASH 2022 Scholar Awards

Published on
Mar 4, 2022
in Cornerstone Blog
Our Scientists’ Research Highlighted In the News
Learn about novel findings and new funding from our Children’s Hospital of Philadelphia researchers.

3-D Genome Mapping Uncovers Possible Treatment Targets in Lupus

Published on
Jul 13, 2020
in Cornerstone Blog
Nature Communications
Using a novel 3-D mapping of the genome of a particular cell type, researchers at CHOP identified new possible treatment targets in lupus.

In the News: Chromatin Rebuilding, Hemophilia Oral Treatment, Linking CVD and CKD, New Algorithm Detects Genetic Variants

Published on
Dec 13, 2019
in Cornerstone Blog
In the News
Learn about developments in chromatin rebuilding, novel hemophilia treatment, linking heart and kidney disease, and genetic sequencing.

Flipping a Gene Switch Reactivates Fetal Hemoglobin, May Reverse Sickle Cell Disease

Published on
Jan 14, 2014
in Cornerstone Blog
Hematologists have long sought to reactivate fetal hemoglobin as a treatment for children and adults with sickle cell disease (SCD). Researchers at CHOP have manipulated key biological events in adult blood cells to produce a form of hemoglobin normally absent after the newborn period.

Izumi Laboratory

Izumi Laboratory

The Izumi Lab aims to elucidate the molecular mechanism of pediatric neurodevelopmental genetic disorders toward the goals of identifying key pathways/molecules that can be used as therapeutic targets in these diagnoses.

Izumi Laboratory Research Overview

View an overview of the research conducted at the Izumi Laboratory

Center for Spatial and Functional Genomics

Center for Spatial and Functional Genomics

The Center for Spatial and Functional Genomics is focused on uncovering the correct functional context of variants identified by genome-wide association studies in order to translate these discoveries into meaningful benefits for pediatric care.

Grant Laboratory

Grant Laboratory

Utilizing high-throughput genomic technologies, combined with bioinformatic approaches, the Grant Lab is unraveling genomic puzzles related to traits that impact the lifecycle.

1 - 10 of 10