Dr. Grinspan's research program focuses on oligodendrocytes, cells of the central nervous system that synthesize the myelin sheath required for transmission of nervous impulses. Her research seeks to understand the signaling pathways that regulate oligodendrocyte maturation and how they are perturbed in diseases such as multiple sclerosis, HIV, and perinatal white matter injury.
Dr. Davidson works to understand the molecular basis of childhood onset neurodegenerative diseases and the development of gene and small molecule therapies for treatment. She also focuses on how noncoding RNAs participate in neural development and neurodegenerative disease processes, and how they can be harnessed for therapies.
As the recipient of a Novel Research Grant from the Lupus Research Alliance, Andrea Knight, MD, a physician in the division of Rheumatology, is working to better understand why children with systemic lupus erythematosus (SLE) experience mental health problems.
A simple question raised by a concerned parent can often kick-start lines of research at Children's Hospital of Philadelphia. This week in the news, those sorts of everyday queries - whether they're about how to breastfeed, why parents should follow a vaccine schedule, or how mechanical circulatory support devices work - led to exciting headline-making stories.
Many research projects aim to keep things on track, from healthcare expenditures to patients’ long-term health. Make certain that you know of the research happenings this week at The Children’s Hospital of Philadelphia by reading on for more highlights.