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Results for CRISPR

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Ophir Shalem, PhD
Ophir Shalem

Dr. Shalem’s research focuses on translational target discovery for a range of neurodegenerative diseases. He combines technology development of large-scale CRISPR-based perturbation screens with application of such technology together with additional genomic approaches.

E-mail:
shalemo [at] chop.edu
Will Bailis, PhD
Will Bailis

Dr. Bailis aims to understand how metabolism underlies immunology and disease, by controlling the biochemistry of cells and tissues. His lab does so using in vitro and in vivo CRISPR engineering of primary human and mouse immune cells, with the goal of developing diet and metabolite based therapies.

E-mail:
bailisw [at] chop.edu
Christopher J. Cardinale, MD, PhD
Christopher J. Cardinale

Dr. Cardinale's research is focused on understanding the mechanisms of gene expression and gene regulation in autoimmune diseases, including inflammatory bowel disease, type 1 diabetes, and systemic sclerosis. He uses data from large-scale genomic studies to identify disease-causing genetic variants and functionally explore the target genes of those variants.

E-mail:
cardinalec [at] chop.edu
Beverly L. Davidson, PhD
Photo of Beverly L. Davidson, PhD

Dr. Davidson works to understand the molecular basis of childhood onset neurodegenerative diseases and the development of gene and small molecule therapies for treatment. She also focuses on how noncoding RNAs participate in neural development and neurodegenerative disease processes, and how they can be harnessed for therapies.

E-mail:
davidsonbl [at] chop.edu
Wei Tong, PhD
Wei Tong

Dr. Tong investigates cytokine receptor signaling in normal and neoplastic hematopoietic development. She uses integrated approaches encompassing biochemistry, molecular biology, mouse models, and primary human samples to understand signaling events emanating from cytokine receptors that regulate the development of hematopoietic stem/progenitor cells.

E-mail:
tongw [at] chop.edu
Deborah L. French, PhD
Deborah French

Dr. French came to CHOP in 2008 to establish the Human Pluripotent Stem Cell Core in the Center for Cellular and Molecular Therapeutics. She is an internationally recognized researcher involved in multi-investigator teams that utilize pluripotent stem cells for modeling human disease to study mechanism, development, and establish new therapeutic modalities.

E-mail:
frenchd [at] chop.edu
Amanda M. Ackermann, MD, PhD
Amanda M. Ackermann

Dr. Ackermann studies diabetes (types 1 and 2) and congenital hyperinsulinism using mouse models, cell lines, and primary human tissue. She aims to identify novel pathways regulating beta cell insulin secretion, leading to innovative therapeutic strategies for these disorders. Current studies include in vivo mouse physiology, ex vivo human islet physiology, CRISPR-Cas9 gene editing, epigenetic modification, and single-cell functional genomics.

E-mail:
ackermanna [at] chop.edu
Carlo Castruccio Castracani, PhD
Carlo Castruccio Castracani

Dr. Castracani’s research work is focused on the most common form of X-linked sideroblastic anemia which results from mutations in the ALAS2 gene and inhibits normal heme biosynthesis.

E-mail:
castruccic [at] chop.edu

In the News: Foundational Gift, Gates Grant, Community-engaged Research

Published on
Feb 17, 2023
in Cornerstone Blog
In the News: Foundational Gift, Community Partnerships
In this news roundup, learn how CHOP researchers are advancing research for neurological diseases and engaging in community collaborative research.

In the News: Community-Driven Research, CRISPR, RNA Sequencing, Cover of the Year

Published on
Feb 3, 2023
in Cornerstone Blog
In the News
In this news roundup, we celebrate research tools new and old, from RNA sequencing to gene editing to the best tool of all: collaboration.
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In this section

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  • Romberg Laboratory (1)
  • Song Laboratory (1)
  • Spatial and Functional Genomics Research Affinity Group (1)
  • Stress Neurobiology Program (1)

In this section

Filter By

  • Principal Investigator / Faculty (7)
  • Research Administration (1)
  • Researcher / Lab Personnel (1)

Organizations

  • Raymond G. Perelman Center for Cellular and Molecular Therapeutics (14)
  • Center for Autism Research (6)
  • Center for Childhood Cancer Research (6)
  • Center for Computational and Genomic Medicine (6)
  • Center for Injury Research and Prevention (6)
  • Department of Pediatrics (5)
  • Center for Applied Genomics (4)
  • Clinical Futures (4)
  • Department of Pathology and Laboratory Medicine (4)
  • Division of Human Genetics (4)
  • PolicyLab (4)
  • Department of Anesthesiology and Critical Care Medicine (3)
  • Department of Biomedical and Health Informatics (3)
  • Office of Academic Training and Outreach Programs (3)
  • Roberts Individualized Medical Genetics Center (3)
  • Akizu Laboratory (2)
  • Bailis Laboratory (2)
  • Department of Child and Adolescent Psychiatry and Behavioral Sciences (2)
  • Division of Allergy and Immunology (2)
  • Division of Cardiology (2)
  • Division of Hematology (2)
  • Division of Neurology (2)
  • Division of Oncology (2)
  • Epilepsy NeuroGenetics Initiative (ENGIN) (2)
  • Grant Laboratory (2)
  • Lifespan Brain Institute (2)
  • Shalem Laboratory (2)
  • Wells Laboratory (2)
  • Anderson Laboratory (1)
  • Aquatic Zebrafish Core (1)
  • Blobel Laboratory (1)
  • Cell and Gene Therapy Collaborative (1)
  • Center for Data-Driven Discovery in Biomedicine (1)
  • Center for Mitochondrial and Epigenomic Medicine (1)
  • Center for Spatial and Functional Genomics (1)
  • Center for Violence Prevention (1)
  • CHOP Microbiome Center (1)
  • Clinical In Vivo Gene Therapy (1)
  • Department of Radiology (1)
  • Department of Surgery (1)
  • Division of Cancer Pathobiology (1)
  • Division of Emergency Medicine (1)
  • Division of Endocrinology and Diabetes (1)
  • Division of Gastroenterology, Hepatology, and Nutrition (1)
  • Division of Nephrology (1)
  • Division of Pulmonary and Sleep Medicine (1)
  • Friedreich’s Ataxia Center of Excellence (1)
  • Henrickson Laboratory (1)
  • Human Pluripotent Stem Cell Core (1)
  • mHealth Research Affinity Group (1)
  • PennCHOP Microbiome Program (1)
  • Pennsylvania Pediatric Medical Device Consortium (1)
  • Research Vector Core (1)
  • Romberg Laboratory (1)
  • Song Laboratory (1)
  • Spatial and Functional Genomics Research Affinity Group (1)
  • Stress Neurobiology Program (1)
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