Results for C. elegans (Worms)

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Marni J. Falk, MD
Marni J. Falk

Dr. Falk is a Clinical Geneticist who serves as executive director of the Mitochondrial Medicine Frontier Program. Her translational research lab investigates the causes and global metabolic consequences of mitochondrial disease, as well as targeted therapies, in C. elegans, zebrafish, mouse, and human tissue models of genetic-based respiratory chain dysfunction.

E-mail:
falkm [at] chop.edu

An Existing Drug May Have Therapeutic Potential in Mitochondrial Disease

Published on
Feb 26, 2019
in Press Releases
New preclinical findings from extensive cell and animal studies suggest that a drug already used for a rare kidney disease could benefit patients with some mitochondrial disorders—complex conditions with severe energy deficiency for which no proven effective treatments exist. Future clinical research is needed to explore whether the drug, cysteamine bitartrate, will meaningfully benefit patients.

Can Vitamins and Dietary Supplements Benefit Patients with Mitochondrial Disease?

Published on
Jan 10, 2018
in Press Releases
CHOP Researchers Co-Author Expert Review of Nutritional Interventions

Scientific Symposium Emphasizes Future Directions of Research Institute

Published on
May 9, 2017
in Cornerstone Blog
Scientific Symposium
Synapses were firing throughout the conference room in the Colket Translational Research Building as attendees at the 2017 Research Institute Scientific Symposium held May 2 learned about their colleagues' intriguing research endeavors. The four sessions' themes aligned smartly with the Research Institute's strategic planning process and overall mission of the Children's Hospital of Philadelphia.

Restoring Cellular Energy Could Lead to Mitochondrial Disease Treatments

Published on
Apr 21, 2015
in Cornerstone Blog
By using existing human drugs to improve metabolism and restore shortened lifespans in microscopic worms, scientists have set the stage for human clinical trials of possible innovative therapies for mitochondrial disease.

Mitochondrial Medicine Research Group Laboratory

Mitochondrial Medicine Research Group Lab

The Mitochondrial Medicine Research Laboratory investigates the genetic etiologies, pathophysiologic mechanisms, and therapeutic targets of mitochondrial disease.  The lab applies state-of-the-art technologies and approaches in diverse animals (C. elegans worms, D. rerio zebrafish, M.

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