Results for Bone Marrow Failure

Dr. Olson aims to improve diagnostics and treatment of bone marrow failure (BMF) syndromes, and to improve clinical hematopoietic stem cell transplantation (HSCT) outcomes. He conducts clinical trials of HSCT for non-malignant hematologic diseases. His laboratory explores both basic and translational research focused on genomics of BMF and the impact of BMF on hematopoietic niche function during HSCT.

Dr. Kurre's laboratory has longstanding expertise in Fanconi Anemia (FA), a genetic condition with prominent hematologic complications. With training in transplantation and hematopoietic stem cell biology, he hopes to improve the understanding of the progressive hematopoietic failure in patients with bone marrow failure and FA, broaden diagnostic approaches, and develop next generation therapies.

Dr. Warren studies normal and aberrant hematopoiesis, with a special interest in granulopoiesis. Her research aims to understand the pathogenesis of severe congenital neutropenia and its risk for malignant transformation. She has a clinical interest in neutropenia syndromes including clinical trials.

Dr. Tong investigates cytokine receptor signaling in normal and neoplastic hematopoietic development. She uses integrated approaches encompassing biochemistry, molecular biology, mouse models, and primary human samples to understand signaling events emanating from cytokine receptors that regulate the development of hematopoietic stem/progenitor cells.

Dr. Bunin's current research focuses on the development of hematopoietic stem cell graft engineering for allogeneic transplantation to minimize graft-versus-host disease (GVHD), promote engraftment and immune reconstitution. She has also developed protocols for rapid manufacture of viral cytotoxic T lymphocytes to treat or prevent life threatening viral infections post hematopoietic stem cell transplant.

Narasaiah Kovuru’s research focuses on understanding the origins of hematopoietic failure/bone marrow failure in Fanconi Anemia working with the murine model.

Suying Liu leads the research project into the clonal restraints of hematopoiesis in an inherited bone marrow failure syndrome, Fanconi Anemia, to promote better understanding and treatment of pediatric hematological disorders.

Omar Banda investigates therapeutic applications of novel nanoparticle delivery systems for the treatment of Fanconi Anemia.

Jian Meng Fan is a research technician III in Dr. Kurre’s Laboratory.