Dr. Zemel's overall research program aims to improve the understanding of lifelong health and how it relates to childhood antecedents of physical growth and maturation, body composition, population ancestry/genetics, and lifestyle factors. Such insight has practical implications for disease prevention and lifelong wellness, as well as broader scientific implications for understanding human plasticity and evolution.
Dr. McCormack investigates the intersection of neuroendocrinology and metabolism. Her translational research program involves two areas. The first involves studying those with genetic disorders, including primary mitochondrial diseases and Friedreich's ataxia, with characterized risk for diabetes mellitus. Second, Dr. McCormack focuses on brain disorders associated with excess weight gain, including brain tumor-related hypothalamic obesity syndrome and idiopathic intracranial hypertension.
Dr. Stallings is working on intervention trials involving three chronic diseases with nutrition-related abnormalities resulting in meaningful adverse outcomes: cystic fibrosis (new drugs), sickle cell disease (vitamin A) and chronic pancreatitis (enzyme replacement drug).
Dr. Pacifici's biomedical research spans three decades and has explored mechanisms of skeletal development and growth in fetal and postnatal life. Specifically, his focus has been on identifying the cellular and molecular mechanisms that regulate the differentiation of progenitor cells and permit assembly of distinct skeletal structures, and on aberrations of these mechanisms in pediatric skeletal disorders.
In the lab of Paula Oliver, PhD, associate professor of Pathology at Children’s Hospital of Philadelphia, a group of researchers led by Awo Layman, PhD; Guoping Deng, PhD; and Claire O’Leary, PhD, studied the influential events that transpire when, as Dr. Layman described it to us, a type of immune cell called a regulatory T cell suffers a “loss of identity.”
If you're eager to learn and a creator of change - which pretty much covers everyone here at the Research Institute - then you'll want to know about what's happening at the Pediatric Academic Societies Annual Meeting (PAS), the largest international meeting focusing on research in child health.