The Wilson Lab studies the inherited neuro- and cardio-degenerative mitochondrial disorder, Friedreich ataxia (FA). The lab also constructed the first random shRNA-expressing libraries and is using these libraries for drug discovery in a variety of disorders.
The Clinical Translational Core and its three sub-cores — Recruitment and Cohort Selection; Phenotyping; and Data Management, Integration, and Sharing — provide a comprehensive set of services designed to enhance the impact and rigor of clinical translational research on Intellectual and Developmental Disabilities.
Building upon Children’s Hospital of Philadelphia’s legacy as one of the preeminent pediatric research institutions in the world, Bryan Wolf, MD, PhD, served as Executive Vice President and Chief Scientific Officer from 2015 to June 1, 2021, overseeing implementation of an ambitious, faculty-led strategic plan to make the most of the Research Institute’s unique resources, infrastructure, intellect, and talent to conduct transformational research initiatives with the highest scientific integrity from bench to bedside.
The Computational Epigenetics Lab develops novel algorithms and big data analytics to understand epigenetic cell identity and its dynamics in cell fate transition, organismal development, and human disease.
The divisions of Pathology Informatics at Children's Hospital of Philadelphia (CHOP) and the Hospital of the University of Pennsylvania (HUP) have partnered with the DBHi Clinical Informatics Fellowship program to offer a pathology informatics concentration within the ACGME accredited Clinical Informatics fellowship.
Yi Xing, PhD is Executive Director of the Department of Biomedical and Health Informatics. Dr. Xing’s groundbreaking research fits well with DBHi’s mission by merging the fields of computational biology, biomedical data science, RNA genomics, human genetics, precision medicine, and immuno-oncology. He is one of the premier investigators in this space, playing a pivotal role in developing new genomic technologies and computational methods, and leading collaborative studies aimed at understanding how the human genome and its gene products contribute to development and disease. He has an extensive publication record in bioinformatics, genomics, and RNA biology and is recognized internationally for his expertise in the fields of computational and experimental RNA biology.