Dr. Weiss' research focuses on epidemiology of pediatric sepsis and mitochondrial dysfunction in sepsis-associated organ injury. The driving hypothesis for his research is that alterations in mitochondrial bioenergetics contribute to organ injury and immune dysregulation in a subset of children with sepsis.
Dr. McCormack investigates the intersection of neuroendocrinology and metabolism. Her translational research program involves two areas. The first involves studying those with genetic disorders, including primary mitochondrial diseases and Friedreich's ataxia, with characterized risk for diabetes mellitus. Second, Dr. McCormack focuses on brain disorders associated with excess weight gain, including brain tumor-related hypothalamic obesity syndrome and idiopathic intracranial hypertension.
Dr. Falk is a Clinical Geneticist who serves as executive director of the Mitochondrial Medicine Frontier Program. Her translational research lab investigates the causes and global metabolic consequences of mitochondrial disease, as well as targeted therapies, in C. elegans, zebrafish, mouse, and human tissue models of genetic-based respiratory chain dysfunction.
September marks National Childhood Cancer Awareness Month, and this year at Children's Hospital of Philadelphia, we kick-started the commemorative period on the heels of exciting news about breakthroughs in pediatric cancer immunotherapy research.
Differences in mitochondrial function are a major factor in understanding the origins of autism spectrum disorders (ASD), according to a new study led by Douglas Wallace, PhD, director of the Center for Mitochondrial and Epigenomic Medicine at Children's Hospital of Philadelphia, that points way back to genetic vulnerabilities accumulated during ancient human migrations.
Energy continues to build for the role of the mitochondrion in health and disease, a field pioneered by Douglas Wallace, PhD, director of the Center for Mitochondrial and Epigenomic Medicine at Children's Hospital of Philadelphia.
Fitness tools that monitor your daily use of energy, from counting steps to tracking sleep, have exploded in popularity. Researchers are developing better noninvasive, high-resolution methods to estimate how well the fundamental source of that energy - your mitochondria - are working, and they have recently had some important successes. Mitochondria are the tiny energy factories of our cells,
By Bryan A. Wolf, MD, PhD, Chief Scientific Officer and Director of the Research Institute
I always look toward the new year with great optimism and hope, to the promise and potential it brings, and to the experiences that will shape us individually, professionally, and organizationally.