Dr. O'Connor investigates the immunological aspects of heart transplantation in children, specifically the impact of anti-HLA antibodies. The presence of these antibodies can complicate or even prevent a transplant from happening; therefore, reducing or eliminating them before transplant is important for a patient to receive a heart that is compatible with his or her immune system.
Dr. Sgourakis’ research focuses on understanding the intricate molecular mechanisms that determine the vast repertoire of peptide antigens displayed by the proteins of the Major Histocompatibility Complex for immune surveillance by T cells and Natural Killer cells.
Dr. Samelson-Jones is a pediatric hematologist dedicated to improving the lives of children with bleeding and clotting disorders. His research focuses on gene therapy for hemophilia, the biochemical basis of coagulation, and the immune responses to hemophilia therapies.
Dr. Puopolo helped lead the research team that developed and validated multivariate prediction models for neonatal early-onset sepsis risk assessment. Her current research addresses the impacts of maternal immunity, perinatal antibiotic exposure, and neonatal infection on infant and childhood health.