Dr. Grupp develops and conducts preclinical testing of engineered cell therapies and signal transduction inhibitors in leukemia, in pediatric immunotherapy trials, and in the manufacture and use of cellular therapeutics in preclinical, good manufacturing practices, and clinical trial settings. Dr. Grupp leads most CTL019 (CD19 CAR) clinical trials, and his colleagues are the global leaders in highly active CAR T cell therapy.
Dr. Teachey's research focuses on investigating novel therapeutics for children with white blood cell diseases, including ALL and a rare autoimmune disease called Autoimmune Lymphoproliferative Syndrome (ALPS). His research in ALL focuses on studying leukemic cells from children with high-risk disease.
When the immune system inappropriately destroys blood cells, in a relatively rare group of diseases called autoimmune cytopenias, children may suffer for years with anemia, uncontrolled bleeding, and vulnerability to infections, while their parents struggle to find a diagnosis.
The Teachey Lab studies perturbations in leukemic cell signal transduction pathways with the aim of identifying targeted cancer inhibitors and immunotherapies that can treat children with high-risk leukemias and autoimmune lymphoproliferative syndrome.