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Wanding Zhou, PhD
Wanding Zhou
Assistant Professor

Dr. Zhou’s outstanding research interests include mitosis-coupled DNA methylation drift and inference of cell-type-specific epigenetic signals. He developed multiple computational tools for analyzing DNA methylation data and has actively contributed to cancer genomics data analysis.



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Dr. Zhou uses data science to better patient outcomes and quality of life. He is a computational scientist in the Center for Computational and Genomic Medicine at Children’s Hospital of Philadelphia and an assistant professor of Pathology and Laboratory Medicine at the Perelman School of Medicine at the University of Pennsylvania. Dr. Zhou’s lab develops novel algorithms and big data analytics to understand epigenetic cell identity and its dynamics in cell fate transition, organismal development, and human disease.

His team aims to disentangle the cellular and the physiological processes that impact DNA methylation and chromatin states. For example, highly proliferative tissue such as cancer is known for having undergone DNA methylation loss in adult humans. Through analyzing hundreds of human and mice methylomes, Dr. Zhou and his colleagues determined mitotic division to be the primary driving force of this DNA methylation attrition (Nature Genetics, 2018).

Before setting up a lab at CHOP, Dr. Zhou received his PhD in Bioengineering from Rice University in 2013 and postdoctoral training at UT MD Anderson Cancer Center and Van Andel Research Institute.

Education and Training

PhD, Rice University (Bioengineering), 2013

Titles and Academic Titles

Assistant Professor

Publication Highlights

Zhou W, Triche TJ Jr, Laird PW, Shen H. SeSAMe: reducing artifactual detection of DNA methylation by Infinium BeadChips in genomic deletions. Nucleic Acids Res. 2018 Nov; 46(20):e123. doi: 10.1093/nar/gky691. PubMed PMID: 30085201; PubMed Central PMCID: PMC6237738
Zhou W, Dinh HQ, Ramjan Z, Weisenberger DJ, Nicolet CM, Shen H, Laird PW, Berman BP. DNA methylation loss in late-replicating domains is linked to mitotic cell division. Nat Genet. 2018 Apr; 50(4):591-602. doi: 10.1038/s41588-018-0073-4. Epub 2018 Apr 2. PubMed PMID: 29610480; PubMed Central PMCID: PMC5893360
Zhou W, Laird PW, Shen H. Comprehensive characterization, annotation and innovative use of Infinium DNA methylation BeadChip probes. Nucleic Acids Res. 2017 Feb; 45(4):e22. doi: 10.1093/nar/gkw967. PubMed PMID: 27924034; PubMed Central PMCID: PMC5389466
Zhou W, Chen T, Chong Z, Rohrdanz MA, Melott JM, Wakefield C, Zeng J, Weinstein JN, Meric-Bernstam F, Mills GB, Chen K. TransVar: a multilevel variant annotator for precision genomics. Nat Methods. 2015 Nov; 12(11):1002-3. doi: 10.1038/nmeth.3622. PubMed PMID: 26513549; PubMed Central PMCID: PMC4772859
Zhou W, Nakhleh L. Quantifying and assessing the effect of chemical symmetry in metabolic pathways. J Chem Inf Model. 2012 Oct; 52(10):2684-96. doi: 10.1021/ci300259u. Epub 2012 Sep 28. PubMed PMID: 22985501