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Sarah E. Henrickson, MD, PhD
Assistant Professor
Dr. Henrickson investigates the mechanisms of T cell dysfunction in monogenic primary immunodeficiency and chronic inflammatory disease, including asthma and obesity, and primary immunodeficiency.
Bio
The role of T cell immunometabolic function in chronic inflammation is a key focus of Dr. Henrickson’s lab. She and her team are studying the impact of pediatric asthma and obesity on immune function, including response to vaccines. Based on her study of CHOP patients with obesity, asthma, and obese asthma, they are now testing the hypotheses that resulted, working with mouse models of obese asthma and human cells in vitro, as well as starting new human studies.
Dr. Henrickson and her lab also study the mechanisms of T cell dysfunction in primary immunodeficiency. She and her lab have studied the earliest stages of T cell activation and have used whole-exome sequencing to uncover novel causes of immunodeficiency in families with severe persistent skin viral infections with genetic disease. They are also studying immunometabolic function in patients with known primary immunodeficiency to better target mechanism of disease in these patients.
Across these studies, Dr. Henrickson and her team use complementary approaches working with humans and mice, leveraging detailed immunophenotyping and metabolic characterization of immune dysfunction in patients, in order to identify and test mechanistic hypotheses to better treat patients and better understand key immune pathways.
Education and Training
AB, Harvard College (Biochemical Sciences), 2001
MD, PhD, Harvard Medical School (Immunology), 2011
Resident, Boston Combined Residency Program in Pediatrics, 2011-2013
Resident, Children's Hospital of Philadelphia (Pediatrics), 2013-2014
Fellow, Children's Hospital of Philadelphia, Allergy Immunology, 2014-2017
Titles and Academic Titles
Attending Physician
Assistant Professor of Pediatrics
Professional Memberships
American Association of Allergy, Asthma and Immunology
American Association of Immunologists
American College of Allergy, Asthma and Immunology
American Pediatric Association
Clinical Immunology Society
Federation of Clinical Immunology Societies
North American Immuno-Hematology Clinical Education and Research Consortium
Society for Pediatric Dermatology
Professional Awards
AAAAI Foundation Faculty Development Grant (summary: Ballas, JACI, July 2018), 2018-2021
Burroughs-Wellcome Fund CAMS grant recipient (BWF Awards Recognize Young Investigators, Innovative Research), 2018-2023
NIAID K08 recipient (1K08AI135091; “Obesity dysregulates immune and metabolic status in asthma and alters infection susceptibility.”; On the Road to Better Treatments for Obese Asthmatics), 2018-2023
Publication Highlights
PubMed:
Henrickson SE, Manne S, Dolfi DV, Mansfield KD, Parkhouse K, MIstry RD, Alpern ER, Hensley SE, Sullivan KE, Coffin SE, Wherry EJ. Genomic Circuitry Underlying Immunological Response to Pediatric Acute Respiratory Infection. Cell Reports. 2018 Jan; 22: 411-426
Henrickson SE, Perro M, Loughhead SM, Senman B, Stutte S, Quigley M, Alexe G, Iannacone M, Flynn MP, Omid S, Jesneck JL, Imam S, Mempel TR, Mazo IB, Haining WN, von Andrian UH. Antigen Availability Determines CD8+ T Cell-Dendritic Cell Interaction Kinetics and Memory Fate Decisions. Immunity. 2013 Sep; 39: 496-507
Henrickson SE, Mempel TR, Mazo IB, Artyomov MN, Zheng H, Liu B, Flynn M, Senman B, Junt T, Wong HC, Chakraborty AK, UH von Andrian. T cell sensing of antigen dose governs interactive behavior with dendritic cells and sets a threshold for T cell activation. Nat. Immunol. 2008 Mar; 9: 282-291
Mempel T, Henrickson SE and UH von Andrian. T-cell priming by Dendritic cells in Lymph Nodes Occurs in Three Distinct Phases. Nature. 2004 Jan; 427: 154-159
Henrickson SE, Misakian M, Robertson B and JJ Kasianowicz. Asymmetric Driven DNA transport into a Nanometer-scale Pore. Phys. Rev. Letters. 2000 Oct; 85: 3057-3060
Links of Interest
BWF Award Recognizes Young Investigators, Innovative Research (CHOP Research blog, Cornerstone)
Does Past Exposure to the Flu Influence Future Immune Responses? (CHOP Research blog, Cornerstone)
Past Exposures Shape Immune Response in Pediatric Acute Respiratory Infections (Penn Medicine News)
Past Exposures Shape Immune Response in Pediatric Acute Respiratory Infections (Science Daily)