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Sarah E. Henrickson, MD, PhD
Photo of Sarah E. Henrickson
Assistant Professor

Dr. Henrickson investigates the mechanisms of T cell dysfunction in monogenic primary immunodeficiency and chronic inflammatory disease, including asthma and obesity, and primary immunodeficiency.

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Bio

The role of T cell immunometabolic function in chronic inflammation is a key focus of Dr. Henrickson’s lab. She and her team are studying the impact of pediatric asthma and obesity on immune function, including response to vaccines. Based on her study of CHOP patients with obesity, asthma, and obese asthma, they are now testing the hypotheses that resulted, working with mouse models of obese asthma and human cells in vitro, as well as starting new human studies.

Dr. Henrickson and her lab also study the mechanisms of T cell dysfunction in primary immunodeficiency. She and her lab have studied the earliest stages of T cell activation and have used whole-exome sequencing to uncover novel causes of immunodeficiency in families with severe persistent skin viral infections with genetic disease. They are also studying immunometabolic function in patients with known primary immunodeficiency to better target mechanism of disease in these patients.

Across these studies, Dr. Henrickson and her team use complementary approaches working with humans and mice, leveraging detailed immunophenotyping and metabolic characterization of immune dysfunction in patients, in order to identify and test mechanistic hypotheses to better treat patients and better understand key immune pathways.

Education and Training

AB, Harvard College (Biochemical Sciences), 2001

MD, PhD, Harvard Medical School (Immunology), 2011

Resident, Boston Combined Residency Program in Pediatrics, 2011-2013

Resident, Children's Hospital of Philadelphia (Pediatrics), 2013-2014

Fellow, Children's Hospital of Philadelphia, Allergy Immunology, 2014-2017

Titles and Academic Titles

Attending Physician

Assistant Professor of Pediatrics

Professional Memberships

American Association of Allergy, Asthma and Immunology

American Association of Immunologists

American College of Allergy, Asthma and Immunology

American Pediatric Association

Clinical Immunology Society

Federation of Clinical Immunology Societies

North American Immuno-Hematology Clinical Education and Research Consortium

Society for Pediatric Dermatology

Professional Awards

AAAAI Foundation Faculty Development Grant (summary: Ballas, JACI, July 2018), 2018-2021

Burroughs-Wellcome Fund CAMS grant recipient (BWF Awards Recognize Young Investigators, Innovative Research), 2018-2023

NIAID K08 recipient (1K08AI135091; “Obesity dysregulates immune and metabolic status in asthma and alters infection susceptibility.”; On the Road to Better Treatments for Obese Asthmatics), 2018-2023

Publication Highlights

Henrickson SE, Manne S, Dolfi DV, Mansfield KD, Parkhouse K, MIstry RD, Alpern ER, Hensley SE, Sullivan KE, Coffin SE, Wherry EJ. Genomic Circuitry Underlying Immunological Response to Pediatric Acute Respiratory Infection. Cell Reports. 2018 Jan; 22: 411-426
Henrickson SE, Perro M, Loughhead SM, Senman B, Stutte S, Quigley M, Alexe G, Iannacone M, Flynn MP, Omid S, Jesneck JL, Imam S, Mempel TR, Mazo IB, Haining WN, von Andrian UH. Antigen Availability Determines CD8+ T Cell-Dendritic Cell Interaction Kinetics and Memory Fate Decisions. Immunity. 2013 Sep; 39: 496-507
Henrickson SE, Mempel TR, Mazo IB, Artyomov MN, Zheng H, Liu B, Flynn M, Senman B, Junt T, Wong HC, Chakraborty AK, UH von Andrian. T cell sensing of antigen dose governs interactive behavior with dendritic cells and sets a threshold for T cell activation. Nat. Immunol. 2008 Mar; 9: 282-291
Mempel T, Henrickson SE and UH von Andrian. T-cell priming by Dendritic cells in Lymph Nodes Occurs in Three Distinct Phases. Nature. 2004 Jan; 427: 154-159
Henrickson SE, Misakian M, Robertson B and JJ Kasianowicz. Asymmetric Driven DNA transport into a Nanometer-scale Pore. Phys. Rev. Letters. 2000 Oct; 85: 3057-3060

Links of Interest