Robert
 
Gordon
 
Kalb
MD
Email: 
kalb@email.chop.edu
Address: 
Children's Hospital of Philadelphia Abramson Research Center #814 3615 Civic Center Boulevard
215 590 0691
Expertise

I am a Board Certified Adult Neurologist who has been in active and continuous practice since 1987. I have facility in the treatment of a broad range of Neurological Disorders. I have special expertise in the diagnosis and management of ALS patients.

My research areas of expertise related to neuro-degenerative diseases and nervous system development.

In the diseases arena, I have particular proficiency in the molecular and cellular underpinning of adult-onset neurodegenerative pathophysiology. there is an emerging interest in the role of intermediary metabolism and aging in relation to neurodegenerative diseases and I am specifically adept in these processes.

In the development arena, I have expertise in the cellular and molecular basis of activity-dependent development. In addition, spinal cord development is a special strong suit of mine.

In both arenas, I have a comprehensive and up-to-date understanding of how the fields have developed and the most current research.

Appointments
Professor of Neurology in Pediatrics at University of Pennsylvania School of Medicine (2011– present)
Professor of Neurology at University of Pennsylvania School of Medicine (2011– present)
Associate Professor of Pediatrics at University of Pennsylvania School of Medicine (2002 – 2011)
Associate Professor of Neurology at University of Pennsylvania School of Medicine (2002 – 2011)
Education
MD, Medicine, Cornell University Medical College (1982)
B.A., Biology, Wesleyan University (1978)
Selected Publications
Lim, M., Selak, M., Xiang, Z., Krainc, D., Neve, R., Kraemer, B., Watts, J. and Kalb, R.. Reduced activity of AMP-activated protein kinase protects against genetic models of motor neuron disease. Journal of Neuroscience. Vol 32. 2012:1123-1141.
Couthouis, J., Hart, M., Erion, R., King, O., Diaz, Z., Nakaya, T., Ibrahim, F., Kim, H., Mojsilovic-Petrovic, J., Panossian, S., Kim, S., Frackelton, E., Solski, J., Williams, J., Clay-Falcone, D., Elman, L., McCluskey, L., Greene, R., Hakonarson, H., Kalb, R., Lee, V., Trojanowski, J., Nicholson, G., Blair, I., Bonini, N., Van Deerlin, V., Mourelatos, Z., Shorter, J., and Gitler, S.. Evaluating the role of the FUS/TLS-related gene EWSR1 in amyotrophic lateral sclerosis. Human Molecular Genetics. Vol 21. 2012:2899-2911.
Moronetti, L., Dersh, D., Boccitto, M. , Kalb, R,G., and Lamitina, T.. Stress and aging induce distinct polyQ protein aggregation states. Proc Natl Acad Sci USA,. Vol 109. 2012:10587-92.
Boccitto, M, Lamitina, T and Kalb, R. Daf-2 signaling modifies mutant SOD1 toxicity in C. elegans. PloS One. Vol 7. 2012:e33494.
Couthouis J., M.P. Hart, J. Shorter, M. DeJesus-Hernandez, R. Erion, R.E. Oristano, X.A. Liu, D. Ramos, N. Jethava, D. Hosangadi, J. Epstein, A. Chiang, Z. Diaz, T. Nakaya, F. Ibrahim, H.J. Kim, J.A. Solski, K.L. Williams, J. Mojsilovic-Petrovic, C. Ingre, K. Boylan, N. Graff-Radford, D. Dickson, D. Clay-Falcone, L. Elman, L. McCluskey, R. Greene, R.G. Kalb, V.M. Lee, J.Q. Trojanowski, A.C. Ludolph, W.Robberecht, P.M. Andersen, G.A. Nicholson, I.P. Blair, O.D. King, N.M. Bonini, V.M. Van Deerlin, R. Rademakers, Z. Mourelatos, A.D. Gitler:. A yeast functional screen predicts new candidate ALS disease genes. Proc Natl Acad Sci USA. Vol 108. 2011:20881-20890.
Goo-Bo Jeong, Jelena Mojsilovic-Petrovic, Marco Boccitto, and Robert Kalb. Signaling events in axons and/or dendrites render motor neurons vulnerable to mutant superoxide dismutase toxicity. Journal of Neuroscience. Vol 31. 2011:295-299.