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Robert B. (Brad) Lindell, MD
Assistant Professor of Anesthesiology and Critical Care
Dr. Lindell’s research program is centered on the biology of critical illness in children with immune dysfunction. His current translational research is focused on pediatric septic shock and the development of multiple organ dysfunction syndrome (MODS) in critically-ill children.
Bio
Dr. Lindell is a graduate of the University of Georgia and Vanderbilt University School of Medicine. He completed his pediatrics residency training and pediatric critical care fellowship at Children’s Hospital of Philadelphia, where he also served as a chief resident in Pediatrics. He is currently an assistant professor of Anesthesiology and Critical Care and Pediatrics in the Perelman School of Medicine at the University of Pennsylvania and an attending physician in the pediatric intensive care unit at Children’s Hospital of Philadelphia.
Education and Training
BS, University of Georgia (Microbiology), 2007
AB, University of Georgia (Religion), 2007
MD, Vanderbilt University School of Medicine, 2012
Residency, Children’s Hospital of Philadelphia (General Pediatrics, Chief Resident)
Fellowship, Children’s Hospital of Philadelphia (Pediatric Critical Care Medicine)
Titles and Academic Titles
Assistant Professor of Anesthesiology and Critical Care
Attending Physician, CHOP Pediatric Sepsis Program
Professional Memberships
American Academy of Pediatrics, 2012-
Society of Critical Care Medicine, 2016-
Pediatric Acute Lung Injury and Sepsis Investigators, 2016-
- HCT-Cancer Immunotherapy Subgroup, 2017
Professional Awards
CHOP Alumni Organization Research Award, 2014
Resident Boot Camp Award Recipient, American Thoracic Society, 2016
Distinguished Poster Award, American Medical Informatics Association Annual Meeting, 2018
2019, Travel Grant Recipient, St. Jude Pediatric Oncology / Critical Care Symposium, 2019
Early Career Award, Thrasher Research Fund, 2019
Silver Snapshot Award, Society of Critical Care Medicine, 2019
NIH Loan Repayment Program Awardee, 2020
Gold Snapshot Award, Society of Critical Care Medicine, 2022
Publication Highlights
Lindell RB, Meyer NJ. Interrogating the sepsis host immune response using cytomics. Crit Care. 2023 Mar; 27(1):93. PMID: 36941659
Lindell RB, Zhang D, Bush J, Wallace DC, Rabinowitz JD, Lu W, Wherry EJ, Weiss SL, Henrickson SE. Impaired Lymphocyte Responses in Pediatric Sepsis Vary by Pathogen Type and are Associated with Features of Immunometabolic Dysregulation. Shock. 2022 Jun; 57(6):191-199. PMID: 35759301
Lindell RB, Fitzgerald JC, Rowan CW, Flori HR, Di Nardo M, Napolitano N, Traynor DM, Lenz KB, Emeriaud G, Jeyapalan A, Nishisaki A. The use and duration of pre-intubation respiratory support is associated with increased mortality in immunocompromised children with respiratory failure. Crit Care Med. 2022 Mar; PubMed PMID: 35275593
Lindell RB, Wolf MS, Alcamo AM, Silverman MA, Dulek DE, Otto WR, Olson TS, Kitko CL, Paueksakon P, Chiotos K. Immune dysregulation due to Toxoplasma gondii reactivation after allogeneic hematopoietic cell transplant: a case series and review of the literature. Front Pediatr. 2021 Aug; 10;9: 719679. PubMed PMID: 34447731
Lindell RB, Nishisaki A, Weiss SL, Traynor DM, Fitzgerald JC. Risk of mortality in immunocompromised children with severe sepsis and septic shock. Crit Care Med. 2020 Jul; 48(7):1026-33. PubMed PMID: 32301846
Active Grants/Contracts
Junior Faculty Pilot Program, CHOP Research Institute (2022 – 2024)
Longitudinal Immune Profiling to Link Immunotypes and Outcomes in Pediatric MODS
Role: Principal Investigator
NIH Loan Repayment Program for Pediatric Research, NICHD (2020 – 2022)
Serial High-Dimensional Immunophenotyping and Functional Testing in Pediatric MODS
Role: Principal Investigator
R21GM146159, NIGMS (2022 – 2024)
Pediatric Sepsis Biorepository and Clinical Database
Role: Co-Investigator
R01HD095976, NICHD (2019 – 2024)
PediAtric ReseArch of Drugs, Immunoparalysis and Genetics during MODS (PARADIGM)
Role: Site PI
R01HL157208, NHBLI (2022 – 2027)
Transfusion and Organ Dysfunction in Pediatric Septic Shock (TROPICS)
Role: Site PI