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Dr. Aplenc investigates ways to improve the outcomes of children with cancer, particularly acute myeloid leukemia, with clinical epidemiology studies and translational research.
Investigators at Children's Hospital of Philadelphia lead over 600 clinical trials aimed at improving pediatric care across all specialties. As chief clinical research Officer of CHOP Research Institute, Dr. Aplenc sets the course for the development and oversight of clinical research and clinical research operations across CHOP Research.
Dr. Aplenc’s research centers on pediatric acute myeloid leukemia (AML), with ongoing clinical epidemiology and translational research projects. His clinical epidemiology research focuses on improving adverse event reporting on clinical trials in the Children's Oncology Group (COG) by merging external data sets to COG clinical trial data. He also leverages data set merging for clinical epidemiology investigations in pediatric AML with a particular focus on cardio-oncology and disparities in treatment outcome.
Dr. Aplenc also leads a Patient-Centered Outcomes Research Institute effort to study medical and patient reported outcomes with various discharge practices after AML chemotherapy administration.
From a translational standpoint, he leads efforts to identify risk alleles for pediatric AML susceptibility and treatment response with genomewide genotyping and next generation sequencing. Finally, he led the recently completed phase III trial for children with AML in the COG and serves as the vice-chair of the COG Strategy AML Committee.
Education and Training
MD, University of Virginia (Medicine), 1994
MS, University of Pennsylvania (Epidemiology and Biostatistics), 2002
PhD, University of Pennsylvania (Epidemiology and Biostatistics), 2011
Titles and Academic Titles
Assistant Vice President and Chief Clinical Research Officer
Professor of Pediatrics and Epidemiology
Senior Teaching Award, UCSD Department of Pediatrics, 1997
Fellow Teaching Award, Children’s Hospital of Philadelphia, 1998
AACR-Bristol-Myers-Squibb Oncology Fellowship in Clinical Oncology Research, American Association for Cancer Research, 1999-2000
Clinical Scientist Training Award, Doris Duke Charitable Foundation, 2000-2005
Pfizer Scholar in Training Award, American Association for Cancer Research, 2003