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Pamela F. Weiss, MD, MSCE
Pamela F. Weiss
Clinical Research Director, Division of Rheumatology

Dr. Pamela Weiss is an experienced academic pediatric rheumatologist with advanced training in clinical epidemiology and a focus on early diagnosis, accurate phenotyping, and targeted treatment of children with juvenile arthritis. Her research consists of a mixture of prospective interventional, prospective observational and retrospective large database-driven work.

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Bio

Dr. Weiss's research focuses on juvenile SpAand juvenile arthirtis.

Juvenile SpA is heterogeneous group of disorders characterized by arthritis, enthesitis (inflammation of the tendon insertions) and axial arthritis (spine and sacroiliac joints) accompanied by overlapping genetic susceptibility. Dr. Weiss has directed efforts to optimize evaluation of early disease phenotype. Prior projects addressed prevalence of sacroiliitis in incident cases of SpA and optimization of the imaging evaluation for detection of axial arthritis.

Dr. Weiss has also developed and validated a composite disease activity outcome that can be used in both routine care and clinical trials. Additionally, MRI is currently the most utilized modality to diagnose sacroiliitis in children, but there is an unmet need for objective measures of inflammation and damage that can be utilized to assess change over time. Dr. Weiss has worked with international colleagues to evaluate scoring systems for inflammation and structural damage at the sacroiliac joint to assess their reliability in the pediatric population.

Dr. Weiss also investigates patient-reported outcomes in juvenile SpA and juvenile arthritis. She has evaluated disparities in PRO across juvenile arthritis categories and is working to incorporate PRO evaluation into routine clinical assessments and outcomes for clinical trials.

Since there is no standardized approach to the initial treatment of juvenile arthritis, understanding the comparative effectiveness of the diverse therapeutic options and standardization of care will result in better health outcomes. Dr. Weiss co-chaired the American College of Rheumatology's 2013 update of the juvenile arthritis treatment recommendations. She also worked with the Childhood Arthritis and Rheumatology Research Alliance to develop consensus treatment plans for systemic and polyarticular arthritis. She is currently a co-investigator on a PCORI grant to study the comparative effectiveness of the polyarticular juvenile arthritis consensus treatment plans.

Education and Training

BA, Princeton University (Molecular Biology), 1998

MD, Albert Einstein College of Medicine, 2002

MSCE, University of Pennsylvania (Clinical Epidemiology and Biostatistics), 2009

Titles and Academic Titles

Clinical Research Director, Division of Rheumatology

Chair, Clinical Trials Research Affinity Group

Associate Professor of Pediatrics

Professional Memberships

American Academy of Pediatrics, 2002-

American College of Rheumatology, 2005-

Arthritis Foundation, 2005-

Childhood Arthritis and Rheumatology Research Alliance, 2005-

Spondyloarthritis Research & Treatment Network, 2012-

National institute of Child Health and Human Development, 2012-

Spondyloarthritis Research and Treatment Network, 2012-

Professional Awards

American Women's Medical Association Janet M. Glasgow Achievement Citation, Albert Einstein Medical College of Medicine, 2002

American College of Rheumatology/Research Education Fund Medical and Pediatric Resident Research Award, 2008

Professional Educator Award, Arthritis Foundation, 2012

Spondylitis Association of America-Jane Bruckel Young Investigator Award, 2014

Publication Highlights

Weiss PF, Xiao R, Brandon T, Biko D, Maksymowych W, Lambert RG, Jaremko J, Chauvin NA. Radiographs in screening for sacroiliitis in children: what is the value?. Arthritis Res Ther. 2018 Jul; 20(1):141. doi: 10.1186/s13075-018-1642-8. PMID: 29996925
Weiss PF, Maksymowych W, Lambert RG, Jaremko J, Biko D, Paschke J, Brandon T, Chauvin NA. Feasibility and Reliability of the Spondyloarthritis Research Consortium of Canada Sacroiliac Joint Inflammation Score for Children with Spondyloarthritis. Arthritis Res Ther. 2018 Mar; 20(1):56. PMID: 29566735
Weiss PF, Xiao R, Brandon TG, Pagnini I, Wright TB, Beukelman T, Morgan E, Feudtner C. Comparative effectiveness of tumor necrosis factor agents and disease-modifying antirheumatic therapy in children with enthesitis-related arthritis: the first year after diagnosis. J Rheumatol. 2018 Jan; 45 (1): 107-114. PMID: PMC5750113
Brandon TG, Becker BD, Bevans KB, Weiss PF. Patient Reported Outcomes Measurement Information System (PROMIS) Tools for Collecting Patient Reported Outcomes in Children with Juvenile Arthritis. Arthritis Care Res. 2017 Mar; 69 (3): 393-402. PMCID: PMC5102825
Weiss PF, Xiao R, Biko DM, Chauvin NA. Assessment of Sacroiliitis at diagnosis of juvenile spondyloarthritis by radiography, magnetic resonance imaging, and clinical examination. Arthritis Care Res. 2016 Feb; 68(2): 187-194. PMCID: PMC4720597