In This Section
Dr. Terry's research focuses on the mechanisms of malabsorption in congenital diarrheal disorders and short bowel syndrome.
The epithelial lining of the intestine allows for absorption of nutrients, electrolytes, and fluid while preventing unwanted microbes from entering the body. One cellular subtype within the epithelium, the enteroendocrine population, secretes hormones that direct digestion and absorption. Several disorders which disrupt the enteroendocrine lineage cause a congenital diarrheal disorder. Further, one of the secreted hormones, GLP-2, is a known treatment for short bowel syndrome.
Using animal models, Dr. Terry and her lab team investigate how the enteroendocrine lineage is specified by different transcription factors. These studies will provide a better understanding of why disruption of the enteroendocrine system causes diarrhea, identifying novel ways to treat the diarrheal illness.
Further, thanks to the generosity of patients and their families, Dr. Terry collaborates with the Ghanem Lab to maintain an Enteroid Biorepository. Enteroids are three-dimensional "mini-guts" grown in culture from the epithelial cells of a single biopsy. Thus, with patient-derived tissue in culture, nutrient absorption and electrolyte secretion characteristics can be determined in a variety of disease states. For patients with congenital diarrheal disorders or short bowel syndrome, these enteroids will provide an excellent model system for future drug screening.
Education and Training
ScB, Brown University (Biochemistry), 1998
MD, University of Pennsylvania, 2006
PhD, University of Pennsylvania (Development), 2006
Fellowship, Children's Hospital of Philadelphia (Pediatric Gastroenterology), 2012
Titles and Academic Titles
Assistant Professor of Pediatrics
North American Society for Pediatric Gastroenterology, Hepatology and Nutrition, 2009-
American Gastroenterological Association, 2010-
Teaching and Tomorrow Fellow, NASPGHAN (North American Society for Pediatric Gastroenterology, Hepatology, and Nutrition) Conference, 2007
Simon Komarov Gastroenterology Fellow Research Competition in Philadelphia, Third Prize, 2012
NASPGHAN Nutrition Prize, 2015
Certificate of Recognition for Scientific Accomplishment As An Early Stage Investigator, Digestive Diseases Week, 2015
Fellows' Faculty Teaching Award, Division of Gastroenterology, Hepatology, and Nutrition, 2016