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terryn [at] email.chop.edu
Location - People View
Room 1115, 11th Floor

3615 Civic Center Blvd
Philadelphia, PA 19104
United States

Natalie A. Terry, MD, PhD
Natalie A. Terry, MD, PhD
Attending Physician

Dr. Terry's research focuses on the mechanisms of malabsorption in congenital diarrheal disorders and short bowel syndrome.

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Bio

The epithelial lining of the intestine allows for absorption of nutrients, electrolytes, and fluid while preventing unwanted microbes from entering the body. One cellular subtype within the epithelium, the enteroendocrine population, secretes hormones that direct digestion and absorption. Several disorders which disrupt the enteroendocrine lineage cause a congenital diarrheal disorder. Further, one of the secreted hormones, GLP-2, is a known treatment for short bowel syndrome.

Using animal models, Dr. Terry and her lab team investigate how the enteroendocrine lineage is specified by different transcription factors. These studies will provide a better understanding of why disruption of the enteroendocrine system causes diarrhea, identifying novel ways to treat the diarrheal illness.

Further, thanks to the generosity of patients and their families, Dr. Terry collaborates with the Ghanem Lab to maintain an Enteroid Biorepository. Enteroids are three-dimensional "mini-guts" grown in culture from the epithelial cells of a single biopsy. Thus, with patient-derived tissue in culture, nutrient absorption and electrolyte secretion characteristics can be determined in a variety of disease states. For patients with congenital diarrheal disorders or short bowel syndrome, these enteroids will provide an excellent model system for future drug screening.

Education and Training

ScB, Brown University (Biochemistry), 1998

MD, University of Pennsylvania, 2006

PhD, University of Pennsylvania (Development), 2006

Fellowship, Children's Hospital of Philadelphia (Pediatric Gastroenterology), 2012

Titles and Academic Titles

Attending Physician

Assistant Professor of Pediatrics

Professional Memberships

North American Society for Pediatric Gastroenterology, Hepatology and Nutrition, 2009-

American Gastroenterological Association, 2010-

Professional Awards

Teaching and Tomorrow Fellow, NASPGHAN (North American Society for Pediatric Gastroenterology, Hepatology, and Nutrition) Conference, 2007

Simon Komarov Gastroenterology Fellow Research Competition in Philadelphia, Third Prize, 2012

NASPGHAN Nutrition Prize, 2015

Certificate of Recognition for Scientific Accomplishment As An Early Stage Investigator, Digestive Diseases Week, 2015

Fellows' Faculty Teaching Award, Division of Gastroenterology, Hepatology, and Nutrition, 2016

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