D.D.S, Ph.D.
The Children's Hospital of Philadelphia Translational Research Program in Pediatric Orthopaedics Division of Orthopaedic Surgery Department of Surgery 3615 Civic Center Boulevard Abramson Research Center 902A

Osteoarthritis, cartilage tumors, degeneration of intervertebral disc.

Research Associate Professor of Orthopaedic Surgery at University of Pennsylvania School of Medicine (2012– present)
Ph.D., Biochemistry, Osaka University (1987)
D.D.S, Osaka University (1983)
Selected Publications
Shimono, K., Tung, W. E., Macolino, C., Chi, A. H., Didizian, J. H., Mundy, C., Chandraratna, R. A., Mishina, Y., Enomoto-Iwamoto, M., Pacifici, M., Iwamoto, M.. Potent inhibition of heterotopic ossification by nuclear retinoic acid receptor-gamma agonists. Nat Med. Vol 17(4) . 2011:454-60.
Yasuhara, R., Ohta, Y., Yuasa, T., Kondo, N., Hoang, T., Addya, S., Fortina, P., Pacifici, M., Iwamoto, M., Enomoto-Iwamoto, M.. Roles of beta-catenin signaling in phenotypic expression and proliferation of articular cartilage superficial zone cells. Lab Invest. 2011.
Zhang, X., Siclari, V. A., Lan, S., Zhu, J., Koyama, E., Dupuis, H. L., Enomoto-Iwamoto, M., Beier, F., Qin, L.. The critical role of the epidermal growth factor receptor in endochondral ossification. J Bone Miner Res. 2011.
Mundy, C., Yasuda, T., Kinumatsu, T., Yamaguchi, Y., Iwamoto, M., Enomoto-Iwamoto, M., Koyama, E., Pacifici, M.. Synovial joint formation requires local Ext1 expression and heparan sulfate production in developing mouse embryo limbs and spine. Dev Biol. Vol 351(1) . 2011:70-81.
Kondo, N., Yuasa, T., Shimono, K., Tung, W., Okabe, T., Yasuhara, R., Pacifici, M., Zhang, Y., Iwamoto, M., Enomoto-Iwamoto, M.. Intervertebral Disc Development Is Regulated by Wnt/beta-catenin Signaling. Spine (Phila Pa 1976). Vol 36(8) . 2011:E513-E518.
Williams, J. A., Kane, M., Okabe, T., Enomoto-Iwamoto, M., Napoli, J. L., Pacifici, M., Iwamoto, M.. Endogenous retinoids in mammalian growth plate cartilage: analysis and roles in matrix homeostasis and turnover. J Biol Chem. Vol 285(47) . 2010:36674-81.
Yasuhara, R., Yuasa, T., Williams, J. A., Byers, S. W., Shah, S., Pacifici, M., Iwamoto, M., Enomoto-Iwamoto, M.. Wnt/beta-catenin and retinoic acid receptor signaling pathways interact to regulate chondrocyte function and matrix turnover. J Biol Chem. Vol 285(1) . 2010:317-27.
Yuasa, T., Kondo, N., Yasuhara, R., Shimono, K., Mackem, S., Pacifici, M., Iwamoto, M., Enomoto-Iwamoto, M.. Transient activation of Wnt/{beta}-catenin signaling induces abnormal growth plate closure and articular cartilage thickening in postnatal mice. Am J Pathol. Vol 175(5) . 2009:1993-2003.
Williams, J. A., Kondo, N., Okabe, T., Takeshita, N., Pilchak, D. M., Koyama, E., Ochiai, T., Jensen, D., Chu, M. L., Kane, M. A., Napoli, J. L., Enomoto-Iwamoto, M., Ghyselinck, N., Chambon, P., Pacifici, M., Iwamoto, M.. Retinoic acid receptors are required for skeletal growth, matrix homeostasis and growth plate function in postnatal mouse. Dev Biol. Vol 328(2) . 2009:315-27.
Nagayama, M., Iwamoto, M., Hargett, A., Kamiya, N., Tamamura, Y., Young, B., Morrison, T., Takeuchi, H., Pacifici, M., Enomoto-Iwamoto, M., Koyama, E.. Wnt/beta-catenin signaling regulates cranial base development and growth. J Dent Res. Vol 87(3) . 2008:244-9.