Ph.D., D.Sc.
CHOP 3615 Civic Center Blvd Room 1102 ARC 4399

CVI Program Unit(s):
Lipid / Atherosclerosis / CAD / ACS / Prevention

CVI Research Description:
Elucidation of the molecular mechanisms underlying the anti-atherogenic properties of HDL and apolipoproteins A-I and E.

The study of the structure-function relationships of plasma lipoproteins and apolipoproteins, and HDL-mediated cholesterol transport. A range of physical-biochemical methods are employed in conjunction with cell culture systems and, more recently, mouse models to generate mechanistic insights into these systems.

Adjunct Professor of Medicine at University of Pennsylvania School of Medicine (2013– present)
Research Professor of Pediatrics at University of Pennsylvania School of Medicine (2000 – 2013)
Ph.D., Southampton University, Southampton, England (1965)
B.Sc., Chemistry and Mathematics, Southampton University, Southampton, England (1962)
Selected Publications
Tanaka M, Koyama M, Dhanasekaran P, Nguyen D, Nickel M, Lund-Katz S, Saito H, Phillips MC. "Influence of Tertiary Structure Domain Properties on the functionality of Apolipoprotein A-I". Biochemistry. Vol 47. 2008:2172-2180.
Duong PT, Weibel GL, Lund-Katz S, Rothblat GH, Phillips MC. "Characterization and Properties of Pre Beta-HDL Particles Formed by ABCA1-mediated Cellular Lipid Efflux to ApoA-I". J Lipid Res. Vol 49. 2008:1006-1014.
Vedhachalam C, Duong PT, Nickel M, Nguyen D, Dhanasekaran P, Sait H, Rothblat GH, Lund-Katz S, Phillips MC. "Mechanism of ATP-binding Cassette Transporter AI (ABCA1)-mediated Cellular Lipid Efflux to Apolipoprotein A-I and Formation of High Density Lipoprotein Particles". J. Biol. Chem.. Vol 282. 2007:25123-25130.
Vedhachalam C, Gehring AB, Davidson WS, Lund-Katz S, Rotyhblat GH, Phillips MC. "ABCA1-induced Cell Surface Binding Sites for ApoA-I". Arterioscler Thromb Vasc Biol.. Vol 27. 2007:1603-1609.
Duong PT, Collins HL, Nickel M, Lund-Katz S, Rothblat GH, Phillips MC. "Characterization of nascent HDL particles and microparticles formed by ABCA1-mediated efflux of cellular lipids to apoA-I". J Lipid Res. Vol 47. 2006:832-843.
Vedhachalam C, Liu L, Nickel M, Dhanasekaran P, Anantharamaiah GM, Lund-Katz S, Rothblat GH, Phillips MC. "Influence of ApoA-I structure on the ABCA1-mediated efflux of cellular lipids". J Biol Chem. Vol 279. 2004:49931-49939.
Saito H, Dhanasekaran P, Nguyen D, Deridder E, Holvoet P, Lund-Katz S, Phillips MC. "Alpha-helix formation is required for high affinity binding of human apolipoprotein A-I to lipids". J Biol Chem. Vol 279. 2004:20974-20981.
Thuahnai ST, Lund-Katz S, Dhanasekaran P, de la Llera-Moya M, Connelly MA, Williams DL, Rothblat GH, Phillips MC. "Scavenger receptor class B type I-mediated cholesteryl ester-selective uptake and efflux of unesterified cholesterol. Influence of high density lipoprotein size and structure". J Biol Chem. Vol 13. 2004:12448-12455.
Saito H, Dhanasekaran P, Nguyen D, Holvoet P, Lund-Katz S, Phillips MC. "Domain structure and lipid interaction in human apolipoproteins A-I and E, a general model". J Biol Chem. Vol 278. 2003:23227-23232.
Jonas A, Phillips MC. "Lipoprotein Structure". Biochemistry of Lipids, Lipoproteins and Membranes. Elsevier; 2008:485-506.