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Dr. Levine has an active laboratory research program that complements and extends his clinical studies. He has identified the molecular basis of several inherited disorders of mineral metabolism. His research interests extend to the molecular basis for embryological development of the parathyroid glands.
Dr. Levine leads the Center for Bone Health at CHOP, which provides clinical services and access to clinical research studies to children and adolescents with nutritional, metabolic, and genetic disorders of bone and mineral metabolism.
Among his current research projects, Dr. Levine is conducting clinical trials to assess the efficacy and safety of recombinant human parathyroid hormone in adults with hypothyroidism; the efficacy and safety of palovarotene in children with multiple osteochondromatosis; and the safety and efficacy of repurposing rifampin as an inducer of CYP3A4 in patients with hypercalcemia and/or hypercalciuria due to genetic mutations in CYP24A1.
In addition, he is working to identify novel genetic forms of vitamin D-dependent rickets as well as novel genetic disorders of parathyroid function.
Education and Training
AB, Rutgers College (Bacteriology), 1972
MD, Drexel University College of Medicine, 1976
Fellowship, NIH-NIDDK (Endocrinology and Genetics), 1982
Titles and Academic Titles
Medical Director, Center for Bone Health
Chief Emeritus, Division of Endocrinology and Diabetes
Lester Baker Endowed Chair in Pediatric Diabetes
Professor of Pediatrics and Medicine
American Society for Clinical Investigation, 1990-
Association of American Physicians, 2003-
American Pediatric Society, 2007-
March of Dimes Basil O'Connor Research Scholar, 1982
Fuller Albright Award, American Society for Bone and Mineral Research, 1990
Young Investigator Award, American Federation for Clinical Research, 1992
Progressive Osseous Heteroplasia Association Research Award, 2000
Distinction in Clinical Endocrinology Award, American College of Endocrinology, 2003
Distinction in Parathyroid Research Award, Hypoparathyroidism Association, 2012
Master of the American College of Endocrinology (MACE), 2015
Distinguished Alumnus Research Award, Drexel University College of Medicine, 2015
Frederic C. Bartter Award in Clinical Investigation, American Society for Bone and Mineral Research, 2018