Ph.D., D.D.S.
The Children's Hospital of Philadelphia Translational Research Program in Pediatric Orthopaedics Division of Orthopaedic Surgery Department of Surgery 3615 Civic Center Boulevard Abramson Research Center 910A

Prevention and treatment for heterotopic ossification.
Connective tissue repair
Development, maintanance, and repair of articular cartilage
Regulation of cell differentiation by nuclear retinoid receptors

Developmental biology of bone and cartilage.
Tissue degeneration of skeletal tissue and muscle.
Microsurgery of small animals.

Research Associate Professor of Orthopaedic Surgery at University of Pennsylvania School of Medicine (2012– present)
Ph.D, Dentistry, Osaka University (1988)
D.D.S, Dental School, Tokushima (1984)
Selected Publications
Leslie Cantley, Cheri Saunders, Marta Guttenberg, Maria Elena Candela, Yoichi Ohta, Rika Yasuhara, Naoki Kondo, Federica Sgariglia, Shuji Asai, Julianne Hugel, Xianrong Zhang, Ling Qin, Jacqueline T. Hecht, Di Chen, Masato Yamamoto, Satoru Toyosawa, John Paul Dormans, Jeffrey D. Esko, Yu Yamaguchi, Masahiro Iwamoto, Maurizio Pacifici, Motomi Enomoto-Iwamoto. Loss of ß-Catenin Induces Multifocal Periosteal Chondroma-like Masses in Mice. American Journal of Pathology. 2013.
Otsuru S, Gordon PL, Shimono K, Jethva R, Marino R, Phillips CL, Hofmann TJ, Veronesi E, Dominici M, Iwamoto M, Horwitz EM.. Transplanted bone marrow mononuclear cells and MSCs impart clinical benefit to children with osteogenesis imperfecta through different mechanisms.. Blood. Vol 120(9) . 2012 Aug:1933-41.
Honami T, Shimo T, Okui T, Kurio N, Hassan NM, Iwamoto M, Sasaki A.. Sonic hedgehog signaling promotes growth of oral squamous cell carcinoma cells associated with bone destruction.. Oral Oncol.. Vol 48(1) . 2012 Jan:49-55.
M. Enomoto-Iwamoto, C. Sunders, Y. Ohta, M. Guttenberg, R. Yasuhara, K. Shimono, N. Kondo, S. Asai, J. Hecht, S. Mackem, D. Chen, J. P. Dormans, M. Iwamoto, M. Pacifici. Loss of ß-Catenin Induces Multifocal Ectopic Chondroma-like Masses in Adult Mice. Transactions/ Orthopaedic Research Society. Vol 37. 2012:0265.
Y. Ohta, T. Okabe, S. Asai, A. Di Rocco, C. Larmour, M. Enomoto-Iwamoto, M. Pacifici, M. Iwamoto. Transcription Factor Erg Is Required for Long-term Articular Cartilage Maintenance.. Transactions/ Orthopaedic Research Society. Vol 37. 2012:341.
S. Asai, K. Shimono, W. Tung, M. Pacifici, M. Iwamoto, M. Enomoto-Iwamoto. Progenitors Recruited to Injured Tendons Are Possible Culprits of Chondroid Degeneration. Transactions/ Orthopaedic Research Society. Vol 37. 2012:141.