M.D., M.Ac.
Department of Anesthesiology and Critical Care Medicine The Children's Hospital of Philadelphia Abramson Research Center 3615 Civic Center Blvd. Suite 402
267 426-7549

I am a pediatrician anesthesiologist with a longstanding interest and extensive experience in the care of children with complex medical conditions, having provided such care in the operating room, pediatric intensive care unit and through my outpatient-based pediatric clinics. The challenge of alleviating persistent pain is of particular interest to me, as is the application of medical acupuncture in pediatric pain management.

Given the limitations on my time due to research responsibilities, my current clinical effort is devoted to the pain management for children and adolescents with complex chronic pain. I am particularly interested in the diagnosis and medical management of chronic pain in children with an underlying neurological, musculoskeletal and inflammatory disease. Medical acupuncture is an important aspect of my practice, and is the most often-cited reason for referral to my clinic.

My research efforts are directed towards understanding how two specific cell populations of the nervous system, multi-potential neural progenitors and astrocytes, are affected by inflammation and/or early-in-life exposure to putative neurotoxins or HIV-1.

Current projects include:
1. The phenotypic and functional characteristics of neurokinin-1 receptor (NK-1R) expression in human multi-potential neural progenitors and astrocytes and the effects of HIV-1 on NK-1R
2. Volumetric analysis of brain MRI in a longitudinally studied cohort of children and adolescents HIV-1 infected early-in-life compared to normative controls. Related to this is an effort to identify blood and cerebral spinal fluid biomarkers of neurocognitive and neuropsychiatric disease progression in pediatric HIV-1.
3. HIV-1 effects on enteric astroglial cells and neuronal architecture in the gut of children HIV-1 infected early-in-life.
4. The role of enteric astroglia in the pathogenesis and symptomatology of inflammatory bowel disease.

Assistant Professor of Anesthesiology and Critical Care at the Hospital of the University of Pennsylvania and the Children's Hospital of Philadelphia (2008 – 2012)
M.Ac., Medical Acupuncture, New England School of Acupuncture (1996)
M.D., Medicine, Tufts Medical School (1977)
none, premedical studies, University of Illinois at Chicago Circle (1973)
R.N., Nursing, Chicago Wesley Memorial Hospital School of Nursing (Northwestern Memorial Hospitals) (1968)
Selected Publications
Serechuck, L., Williams, P.L., Nachman, S., Gadow, K.D., Chernoff, M., Schwartz, L. for the IMPAACT 1055 Team. Prevalence of pain and association with psychiatric symptom severity in perinatally HIV-infected children compared to controls living in HIV-affected households.. AIDS Care. Vol 22(5) . 2010 May:640.
Chernova, I., Lai, J.p., Li, H., Schwartz, L., Tuluc, F., Korchak, H.M., Douglas, S.D., Kilpatrick, L.E.. Substance P (SP) enhances CCL5-induced chemotaxis and intracellular signaling in human monocytes, which express the truncated neurokinin-1 receptor (NK1R).. J Leukocyte Biology. Vol 85. 2009:154-164.
Meshki, J., Douglas, S.D., Lai, J.P., Schwartz, L., Kilpatrick, L.E., Tuluc, F.. Neurokinin 1 receptor mediates membrane blebbing in HEK292 cells through a Rho/ROCK-associated Coiled-coil kinase-dependent mechanism.. J Biological Chemistry. Vol 284(14) . 2009:9280-9289.
Douglas, S.D., Lai, J.P., Tuluc, F., Kilpatrick, L.E.. Neurokinin-1 receptor expression and function in human macrophages and brain.. Annals of the New York Academy of Sciences. Vol 1144. 2008:90-96.
Schwartz, L., Civitello, L., Dunn-Pirio, A., Ryschkewitsch, S., Berry, E., Cavert, W., Kinzel, N., Lawrence, D.M.P., Hazra, R., Major, E.O.. Evidence of HIV-1 infection of neural progenitor cells in archival human pediatric brain tissue.. Journal of Neurovirology. Vol 13(3) . 2007:274-283.
Lawrence, D.P.M., Durham, L., Schwartz, L., Seth, P., Maric, D., Major, E.O.. Human immunodeficiency virus type 1 infection of human brian-derived progenitor cells.. J Virology. Vol 78(14) . 2004:7319-7328.
Quezado, Z.M.N., Veihmeyer, J., Schwartz, L., Nwokoro, N.A., Porter, F.D.. Anesthesia and airway management of pediatric patients with Smith-Lemli-Optiz Syndrome.. Anesthesiology. Vol 97(4) . 2002:1015-1019.
Schwartz, L., Rockoff, M.A., Koka, B.V.. Masseter spams with anesthesia: incidence and implications.. Anesthesiology. Vol 61(6) . 1984:772-775.