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linlan [at] email.chop.edu
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CTRB 9052

3501 Civic Center Blvd
Philadelphia, PA 19104
United States

Research Topics
Lan Lin, PhD
Lan Lin
Researcher

Dr. Lin studies RNA modifications (a.k.a "epitranscriptomics") in human diseases, including cancer. She develops and applies high-throughput sequencing strategies and transcriptome engineering technologies to study the regulation and function of RNA modifications, including A-to-I RNA editing and m6A RNA methylation.

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Bio

Dr. Lin studies post-transcriptional RNA processing and modifications that are important mechanisms for gene regulation and functional diversity in eukaryotic cells. RNA editing has emerged as an important and widespread mechanism for generating transcriptome diversity in eukaryotic cells. Aberrant RNA editing has been implicated in a variety of diseases including neurological diseases and cancer.

The most abundant type of RNA editing is the A-to-I RNA editing (the deamination of adenosine to inosine) mediated by the ADAR family of RNA editing enzymes. Dr. Lin and her lab team combine genomic, bioinformatic, and molecular approaches to study the regulation, genetic variation, and function of A-to-I RNA editing, as well as the roles of RNA editing in shaping complex traits and diseases.

N6-methyladenosine (m6A) is an abundant and dynamically regulated class of RNA base modification in mRNAs and non-coding RNAs. It affects multiple aspects of RNA metabolism and controls developmental transitions by regulating mRNA decay and translation.

Dr. Lin is developing sensitive sequencing methods to detect RNA m6A methylation in a wider array of clinical and biological samples and using transcriptome engineering technologies to investigate the regulatory and functional consequences of m6A methylation.

Education and Training

BS, Peking University (Biotechnology), 2001

PhD, University of California, Los Angeles (Cellular and Molecular Pathology), 2007

Fellowship, University of Iowa (Internal Medicine), 2011

 

Titles and Academic Titles

Researcher

Assistant Professor of Pathology and Laboratory Medicine

Professional Awards

Postdoctoral Travel Award, American Society for Biochemistry and Molecular Biology, 2009, 2010

Publication Highlights

Lin L, Jiang P, Park JW, Wang J, Lu ZX, Lam MP, Ping P, Xing Y. The contribution of Alu exons to the human proteome. Genome Biol. 2018 Dec; 17:15. PMCID: PMC4731929
Park E, Guo J, Shen S, Demirdjian L, Wu YN, Lin L, Xing Y. Population and allelic variation of A-to-I RNA editing in human transcriptomes. Genome Biol. 2018 Jul; 18(1):143. PMCID: PMC5532815
Lin L, Park JW, Ramachandran S, Zhang Y, Tseng YT, Shen S, Waldvogel HJ, Curtis MA, Faull RL, Troncosco JC, Pletnikova O, Ross CA, Davidson BL, Xing Y. Transcriptome sequencing reveals aberrant alternative splicing in Huntington's disease. Hum Mol Genet. 2016 Aug; 25(16):3454-3466. PMCID: PMC5179942
Shen S, Lin L, Cai JJ, Jiang P, Kenkel EJ, Stroik MR, Sato S, Davidson BL, Xing Y. Widespread establishment and regulatory impact of Alu exons in human genes. Proc Natl Acad Sci USA. 2011 Feb; 108(7):2837-42. PMCID: PMC3041063
Lin L, Shen S, Jiang P, Sato S, Davidson BL, Ying Y. Evolution of alternative splicing in primate brain transcriptomes. Hum Mol Genet. 2010 Aug; 19(15):2958-73. PMCID: PMC2901138