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E-mail
loomes [at] email.chop.edu
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3615 Civic Center Blvd
Philadelphia, PA 19104
United States

Research Topics
Kathleen Loomes, MD
Kathleen Loomes
Associate Director, Fred and Suzanne Biesecker Pediatric Liver Center

Dr. Loomes' research is focused on clinical and translational studies in pediatric liver disease. She works with National Institutes of Health-funded national consortia to conduct studies investigating the etiology and treatment for rare pediatric liver diseases including biliary atresia, Alagille syndrome, and others. Dr. Loomes also collaborates with other investigators at Children’s Hospital of Philadelphia to investigate genetic causes of pediatric liver disease.

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Bio

Dr. Loomes' research is focused on clinical and translational studies in pediatric liver disease. Early in her career, Dr. Loomes used genetic mouse models to investigate the role of the Notch ligand Jag1 in development of multiple organ systems affected in the autosomal dominant disorder Alagille syndrome (ALGS). Building on that work, she collaborated with other investigators at CHOP to identify genetic modifiers of liver disease severity in ALGS. She has also worked to identify candidate susceptibility genes for biliary atresia (BA).

Dr. Loomes is the site principal investigator at CHOP for the NIH-funded Childhood Liver Disease Research Network (ChiLDReN) and the Pediatric Acute Liver Failure Immune Response Network (PALF-IRN). In collaboration with the ChiLDReN consortium, Dr. Loomes has participated in multiple observational and interventional studies in rare pediatric liver diseases. The ChiLDReN studies have characterized the natural history of these rare disorders in longitudinal cohorts of children and completed clinical trials in BA and ALGS. Numerous ancillary studies have been conducted using biospecimens collected through ChiLDReN studies, including investigations into novel genetic etiologies of disease.

She has also collaborated to characterize immune cell populations in the liver of patients with indeterminate pediatric acute liver failure. The newly-created PALF-IRN will conduct a clinical trial in this critically ill patient population.

Education and Training

BA, Rice University (Biology), 1988

MD, University of Texas Southwestern Medical School, 1992

Fellowship, Children's Hospital of Philadelphia (Gastroenterology), 1999

Titles and Academic Titles

Associate Director, Fred and Suzanne Biesecker Pediatric Liver Center

Director of Research Training, Gastroenterology and Hepatology Fellowship Training Program

Attending Physician

Professor of Pediatrics

Professional Memberships

North American Society for Pediatric Gastroenterology and Nutrition, 1996-

American Gastroenterological Association, 1996-

American Association for the Study of Liver Disease, 1996-

Professional Awards

Fellows' Teacher of the Year Award, Children's Hospital of Philadelphia, 1996

Researcher of the Year, Delaware Valley Chapter of the American Liver Foundation, 2003

Publication Highlights

Loomes KM, Spino C, Goodrich NP, Hangartner TN, Marker AE, Heubi JE, Kamath BM, Shneider BL, Rosenthal P, Hertel PM, Karpen SJ, Molleston JP, Murray KF, Schwarz KB, Squires RH, Teckman J, Turmelle YP, Alonso EM, Sherker AH, Magee JC, Sokol RJ. Childhood Liver Disease Research Network. Bone Density in Children With Chronic Liver Disease Correlates With Growth and Cholestasis. Hepatology. 2019 Jan; 69(1):245-257. PMID: 30063078
Chapin CA, Burn T, Meijome T, Loomes KM, Melin-Aldana H, Kreiger PA, Whitington PF, Behrens EM, Alonso EM. Indeterminate pediatric acute liver failure is uniquely characterized by a CD103(+) CD8(+) T-cell infiltrate. Hepatology. 2018 Sep; 68(3):1087-1100. PMID: 29603342
Chen Y, Gilbert MA, Grochowski CM, McEldrew D, Llewellyn J, Waisbourd-Zinman O, Hakonarson H, Bailey-Wilson JE, Russo P, Wells RG, Loomes KM, Spinner NB, Devoto M. A genome-wide association study identifies a susceptibility locus for biliary atresia on 2p16.1 within the gene EFEMP1. PLoS Genet. 2018 Aug; 14(8):e1007532. PMID: 30102696
Mitchell E, Loomes KM, Squires RH, Goldberg D. Variability in acceptance of organ offers by pediatric transplant centers and its impact on wait-list mortality. Liver Transpl. 2018 Jun; 24(6):803-809. PMID: 29506323
Tsai EA, Gilbert MA, Grochowski CM, Underkoffler LA, Meng H, Zhang X, Wang MM, Shitaye H, Hankenson KD, Piccoli D, Lin H, Kamath BM, Devoto M, Spinner NB, Loomes KM. THBS2 Is a Candidate Modifier of Liver Disease Severity in Alagille Syndrome. Cell Mol Gastroenterol Hepatol. 2016 May; 2(5):663-675.e2. PMID: 28090565