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2716 South Street
Philadelphia, PA 19146
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Research Topics
Joyce Chang, MD
Photo of Joyce Chang
Attending Physician

Dr. Chang is a clinical investigator focusing on cardiovascular assessment and outcomes of pediatric-onset systemic lupus erythematosus (pSLE). Her research assesses the utility of various screening modalities, including echocardiography, ambulatory blood pressure monitoring, and tonometry, for the early detection of cardiovascular disease. Her research goals are to develop screening protocols and targeted interventions to prevent pSLE-related cardiovascular morbidity and mortality.



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Dr. Chang's primary research interest is in the early detection of cardiac manifestations and prevention of long-term cardiovascular comorbidities of pediatric-onset systemic lupus erythematosus (pSLE). Over the past several years of her academic fellowship, Dr. Chang integrated her clinical interests with formal training in epidemiology and biostatistics to develop a body of work related to the use of echocardiography for the early detection of cardiac disease in children with lupus. This work is supported by the National Heart, Lung, and Blood Institute (NHLBI) and has led to successful interdisciplinary collaborations with researchers in pediatric cardiology.

In addition to echocardiography, Dr. Chang's current research seeks to explore the utility of other non-invasive tests to assess subclinical changes associated with atherosclerotic risk in children and adolescents with pSLE. Specifically, she seeks to determine whether functional vascular abnormalities, such as attenuated nocturnal blood pressure dipping (loss of the normal decrease in blood pressure from daytime to nighttime) and decreases in peripheral vascular reactive hyperemia are associated with structural atherosclerotic vascular changes as measured by carotid intima-media thickness. This work is supported by the Lupus Foundation of America and is a first step in identifying non-invasive measures of atherosclerotic risk that can be used in future trials and in clinical practice. Her long-term goals are to develop standardized screening recommendations and targeted interventions during childhood to prevent future cardiovascular morbidity and mortality in patients with SLE.


Education and Training

AB, Harvard University (Biochemical Sciences), 2008

MD, University of Pennsylvania, 2012

Fellowship, Children's Hospital of Philadelphia (Pediatric Rheumatology), 2018

MSCE, University of Pennsylvania (Clinical Epidemiology), 2018

Titles and Academic Titles

Attending Physician

Assistant Professor of Pediatrics

Professional Memberships

American College of Rheumatology, 2013-

Childhood Arthritis & Rheumatology Research Alliance, 2015-

American Heart Association, 2017-

Professional Awards

Pediatric Rheumatology Symposium Abstract Award, Rheumatology Research Foundation, 2017

Research Poster Day Clinical Abstract Award, Children's Hospital of Philadelphia, 2017

Perelman School of Medicine 21st Century Endowed Scholar, Perelman School of Medicine at the University of Pennsylvania, 2008-2012



Publication Highlights

Kushner CJ, Tarazi M, Gaffney RG, Feng R, Ardalan K, Brandling-Bennett HA, Castelo-Soccio L, Chang JC, Chiu YE, Gmuca S, Hunt RD, Kahn PJ, Knight AM, Mehta J, Pearson DR, Treat JR, Wan J, Yeguez AC, Concha JSS, Patel B, Okawa J, Arkin LM, Werth VP. Evaluation of the reliability and validity of the Cutaneous Lupus Erythematosus Disease Area and Severity Index (CLASI) in paediatric cutaneous lupus among paediatric dermatologists and rheumatologists. Br J Dermatol. 2019 Jan; 180(1):165-171. PMID: 30033560
Chang JC, Xiao R, Mercer-Rosa L, Knight AM, Weiss PF. Child-onset systemic lupus erythematosus is associated with a higher incidence of myopericardial manifestations compared to adult-onset disease. Lupus. 2018 Nov; 27(13):2146-2154. PMID: 30318995
Chang JC, Mandell DS, Knight AM. High Health Care Utilization Preceding Diagnosis of Systemic Lupus Erythematosus in Youth. Arthritis Care Res. 2018 Sep; 70(9):1303-1311. PMID: 29195017
Chang JC, Knight AM, Xiao R, Mercer-Rosa LM, Weiss PF. Use of echocardiography at diagnosis and detection of acute cardiac disease in youth with systemic lupus erythematosus. Lupus. 2018 Jul; 27(8):1348-1357. PMID: 29688145
Kenyon CC, Chang J, Wynter SA, Fowler JC, Long J, Bryant-Stephens TC. Electronic Adherence Monitoring in a High-Utilizing Pediatric Asthma Cohort: A Feasibility Study. JMIR Res Protoc. 2016 Jun; 5(2):e132. PMID: 27335355

Links of Interest