HOW CAN WE HELP YOU? Call 1-800-TRY-CHOP
In This Section
Dr. Jacobs’s current research focuses on several areas, including the biochemical, microbiological, and genetic cause of scarring or stenosis of the laryngotracheal airway, and the development of tissue-engineered cartilage and other novel biomaterials for laryngotracheal reconstruction. Dr. Jacobs is also investigating the mitigation of button battery injuries in infants and children.
Dr. Jacobs and his team were the first to develop and an in vitro- and in vivo-derived cartilage grafts for laryngotracheal reconstruction in a rabbit model. His current research focus is on customizing cartilage grafts for minimally invasive posterior laryngeal expansion procedures. The main thrust of this translatable research has led to the achievement of a successful Frontier Grant application of a translatable research endeavor for pediatric laryngotracheal reconstruction.
Additional research by Dr. Jacobs and his colleagues include the prevention and mitigation of lithium battery injuries in infants and children using both cadaveric and live animal porcine esophagus. In this project the team was able to elucidate the basic mechanism of injury, which involves an alkaline burn from electrically induced hydrolysis of water at the anode pole of the battery. The investigators were also able to demonstrate effective injury reduction with specific mildly acidic beverages such as orange juice and 0.25 percent acetic acid at the time of lithium battery removal and honey and sucralfate (Carafate) in the preoperative time before endoscopic removal. This research has resulted in the National Poison Control Center guidelines being changed in 2018.
Among his notable career achievements to date, Dr. Jacobs received:
- Honorable mention for Basic Research by The Triological Society Council for thesis entitled, "The Development of an In Vitro and In Vivo Derived Tissue-Engineered Cartilage for Pediatric Laryngotracheal Reconstruction in a Rabbit Model"
- Seymour Cohen Award in Pediatric Laryngology at the American Bronchoesophagological Association for “Basic mechanism of button battery injuries and novel mitigation strategies after diagnosis and removal
- Broyles-Maloney Award for Bronchoesophagological Association for use of honey and sucralfate to prevent injuries
- Ellen Friedman Foreign Body Management Award
- Frontier Grant from Children’s Hospital of Philadelphia for extraordinary clinic care, translatable research, and innovation
Education and Training
BA, University of Pennsylvania, 1982
MD, Mt. Sinai School of Medicine, 1986
MLA, University of Pennsylvania College of Arts and Sciences, 2014
Titles and Academic Titles
Medical Director, Center for Pediatric Airway Disorders
Endowed Chair in Pediatric Otolaryngology and Pediatric Airway Disorders
Professor of Otorhinolaryngology: Head and Neck Surgery
American Academy of Otolaryngology-Head and Neck Surgery, 1995-
American Broncho-Esophagological Association, 1999-
American Academy of Pediatrics, Section of Bronchoesophagology, 2000-
American Academy of Pediatrics, Section of Otolaryngology, 2000-
European Laryngological Society, 2012-
American Laryngological Association, 2017-
American Academy of Otolaryngology-Head and Neck Surgery Honor Award, 2001
Honorary Lifetime Member, Israeli Society of Otolaryngology/Head and Neck Surgery, 2009
Fellow, The College of Physicians (Philadelphia), 2012
Triological Society Career Development Award, 2012
Links of Interest
New Bioengineering Lab Paves Way for Pediatric Airway Discoveries (Cornerstone blog)