In This Section

Eiki Koyama, DDS, PhD
Scientist, Biomedical Research Program in Pediatric Orthopaedics

Dr. Koyama's research focuses on Hereditary Multiple Exostoses (HME), a genetic disorder that causes the development of multiple benign tumors on the surface of the metaphyses of long bones. Based on his extensive knowledge of the normal processes of skeletal development and growth, Dr. Koyama's research aims to clarify the molecular mechanisms of HME formation and growth.

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Bio

Dr. Koyama's research program focuses currently focuses on synovial joint development, Hereditary Multiple Exostosis, and temporomandibular joint development and postnatal maintenance.

Specifically, with respect to synovial joint development, the first overt sign of joint development is the appearance of a layer of closely-packed mesenchymal non-chondrogenic cells referred to as interzone. Dr. Koyama and his team have discovered its important roles for joint formation.

The team has also studied several congenital conditions including HME that affects children and young adults. Based on their extensive knowledge of the normal processes of skeletal development and growth, Dr. Koyama and his colleagues would like to clarify the molecular mechanisms of HME formation and growth.

Dr. Koyama also investigates temporomandibular joint (TMJ) development and postnatal maintenance. Mandibular condylar cartilage is essential for functioning of the TMJ and its congenital or acquired aberrations can cause disease, including early onset osteoarthritis. Dr. Koyama and his research team demonstrated that hedgehogs signaling is essential to condylar growth, both structural and functional.

Education and Training

DDS, Matsumoto Dental University, Japan, 1985

PhD, Okayama University, Japan (Developmental Biology), 1993

Titles and Academic Titles

Scientist, Biomedical Research Program in Pediatric Orthopaedics

Research Associate Professor

Professional Memberships

American Society for Bone and Mineral Research, 2005-

American Association of Dental Research, 2010-

Publication Highlights

Shibukawa Y, Young YB, Wu C, Yamada, S, Long F, Pacifici P, Koyama E. Temporomandibular joint formation and condyle growth require Indian hedgehog signaling. Dev Dyn. 2019 Feb; 236(2):426-34. PMID:17191253
Kurio N, Saunders C, T. Bechtold R, Salhab I, Nah HD, Sinha S, Billings PC, Pacifici M and Koyama E. Roles of Ihh signaling in chondroprogenitor function in postnatal condylar cartilage. Matrix Biol. 2018 Apr; 67:15-31. doi: 10.1016/j.matbio.2018.02.011. PMID:29447948
Sinha S, Mundy C, Bechtold T, Sgariglia F, Ibrahim MM, Billings PC, Carroll K, Koyama E, Jones KB, Pacifici M. Unsuspected osteochondroma-like outgrowths in the cranial base of Hereditary Multiple Exostoses patients and modeling and treatment with a BMP antagonist in mice. PLOS Genet. 2017 Apr; 13(4):e1006742. doi: 10.1371/journal.pgen.1006742. PMID: 28445472
Koyama E, Saunders C, Salhab I, Decker RS, Chen I, Um H, Pacifici M, Nah HD. Lubricin is required for the structural integrity and post-natal maintenance of TMJ. J Dent Res. 2014 May; 93(7):663-670. PMID: 24834922
Koyama E, Shibukawa Y, Nagayama M, Sugito H, Young B, Yuasa T. Okabe T. Ochiai T, Kamiya K, Rountree, RB, Kingsley DM, Iwamoto M, Enomoto-Iwamoto M, and Pacifici M. A distinct cohort of progenitor cells participates in synovial joint and articular cartilage formation during mouse limb skeletogenesis. Dev. Biol. 2008 Apr; 316(1):62-73. PMID:18295755