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Dr. Weiss' research focuses on epidemiology of pediatric sepsis and mitochondrial dysfunction in sepsis-associated organ injury. The driving hypothesis for his research is that alterations in mitochondrial bioenergetics contribute to organ injury and immune dysregulation in a subset of children with sepsis.
Dr. Worthen's research program focuses on the mechanisms of acute inflammation in the lung. For more than 30 years he has worked to develop concepts, tools, and approaches to understand how neutrophils are mobilized from the bone marrow, retained within pulmonary capillaries, and migrate into the lung parenchyma and airspaces.