The research in the Sabatino Laboratory is focused on hemophilia, an inherited bleeding disorder. The interests of the laboratory include the study of variants of coagulation factor VIII to understand the biochemical properties of these proteins and to identify novel variants with enhanced function, and the development of gene-based therapeutic approaches for treating hemophilia.

Dr. Samelson-Jones is a pediatric hematologist dedicated to improving the lives of children with bleeding and clotting disorders. His research focuses on gene therapy for hemophilia, the biochemical basis of coagulation, and the immune responses to hemophilia therapies.

Dr. Schofield's research focuses on neurocognitive outcomes of oncology treatment. Her areas of interest are acute and long-term neurotoxicities and cognitive sequelae of cellular therapy, including hematopoietic stem cell transplant and chimeric antigen receptor (CAR) T-cell therapy.

Dr. Schultz's research involves using magnetic resonance imaging to understand brain mechanisms and to create biomarkers that predict who has autism spectrum disorder (ASD), who will develop the disorder, and who will respond well to different interventions. More recently, he has developed a technology and innovation lab to exploit advances in perceptual computing, in order to develop more robust measurements of quantitative traits.

Dr. Schwartz's research focuses on behavioral and psychosocial aspects of cancer and its treatment in adolescents and young adults (AYAs), a group of patients with unique medical and psychosocial challenges. Most of her current studies aim to understand and improve self-management among AYAs.

Relies on extensive experience in leadership positions in institution, independent, and governmental Institutional Review Boards to support investigators while they navigate multicenter research studies.

Dr. Scribano's areas of interest and research involve the epidemiology and prevention of child maltreatment and intimate partner violence, technology use in healthcare, and health services to children in foster care.

Thomas Seacrist's research is focused on how the anatomical and developmental differences between children and adults affect their motion during motor vehicle crashes, improving child crash test dummies, and detecting driving behavior differences between novice teen and experienced adult drivers.

Dr. Seif's research centers on manipulating the human innate and immune systems to treat children with acute lymphoblastic leukemia (ALL). The long-term goal of her research is to identify innate and adaptive immune mechanisms that can be used to treat pediatric ALL more effectively, and with less toxicity, than existing therapies.

Dr. Sengupta is a neonatologist and physician scientist with a long-standing interest in lung health. She studies the mechanisms of circadian regulation of lung inflammation, injury, and repair; and the effect of early life exposures on development and function of pulmonary circadian networks in adulthood.

Dr. Sgourakis’ research focuses on understanding the intricate molecular mechanisms that determine the vast repertoire of peptide antigens displayed by the proteins of the Major Histocompatibility Complex for immune surveillance by T cells and Natural Killer cells.

Dr. Shah's research is centered on understanding obesity and its related complications. Her current work includes clinical and translational studies exploring pathophysiology and modulation of obesity-related adipose tissue and systemic inflammation using human cell lines and clinical trials. She is also involved in clinical studies of outcomes and risk factors of polycystic ovarian syndrome and type 2 diabetes in teens.

Dr. Shah's clinical research interests are focused in the areas of neurofibromatosis type 1 and retinoblastoma. These studies range from translational studies to clinical trials of novel therapeutics to international consortiums studying long-term effects of therapy.

Dr. Shalem’s research focuses on translational target discovery for a range of neurodegenerative diseases. He combines technology development of large-scale CRISPR-based perturbation screens with application of such technology together with additional genomic approaches.

Dr. Shaw is an emergency medicine physician, clinical epidemiologist, and national leader in the fields of pediatric emergency medicine and quality and patient safety. She is most noted for her research in the diagnosis and management of acute pediatric illness and injuries, most notably UTI,
dehydration, and bronchiolitis.

Dr. Shih studies the metabolic interplay between cell types within the neurovascular unit during stroke to develop effective, novel mitochondrial-directed therapeutics to improve post-stroke disability. She works with small and large animal models of childhood arterial ischemic stroke.

Dr. Shu's research focuses on developing and applying suitable statistical methods for assessing comparative safety and effectiveness of medical products.

Dr. Shukla focuses on the study of clinical and patient reported outcomes in robot-assisted laparoscopy and the bladder exstrophy-epispadias complex. He also investigates hypospadias, urinary reflux, hydronephrosis, and complex urinary tract reconstruction.

Dr. Shults works to develop statistical methods for longitudinal data that include semi-parametric approaches to account for subject/cluster level associations and maximum likelihood-based approaches for simulation and analysis of discrete longitudinal outcomes that may have overdispersion.

Dr. Silber is the director of the Center for Outcomes Research at CHOP, and is an internationally known authority on outcomes measurement and severity adjustment for both adult and pediatric applications.

Dr. Silverman studies the fundamental aspects of early-life commensal microbes that influence immune system development and function. He discovered that the MHC-II E molecule prevents type 1 diabetes by shaping the intestinal microbiota early in life.

The principal goal of Dr. Simmons' research program is to elucidate the underlying molecular mechanisms that link an aberrant intrauterine milieu to the later development of diseases in adulthood. She has made many seminal contributions to the understanding of the role that epigenetic modifications play in developmental programming of obesity and type 2 diabetes.

Dr. Simpao, a pediatric anesthesiologist and clinical informatician, has a strong track record of innovation and research. He's led projects that use visual analytics and machine learning models to derive insights and predict outcomes using large healthcare data sets.

Dan Singleton delivers actionable clinical data to researchers and provides tools for efficient data management and reconciling data capture in the clinical domain with secondary use for research purposes.

Dr. Smith is a laboratory animal medicine veterinarian. As Technical Director of the CCMT Comparative Medicine Services Core, he helps guide promising therapeutics and devices from discovery and developmental studies through nonclinical studies.

Dr. Smith-Whitley's research focuses on sickle cell survivorship: predicting and preventing long-term, chronic, and life-threatening complications of the disease.

Dr. Snyder is a pediatric hematologist oncologist focused on improving the lives of people living with vascular anomalies. She is involved with national and international endeavors to create educational programs and investigational registries, investigate treatments, and author publications in this discipline.

Dr. Song works to elucidate the cellular and molecular basis governing the formation, maintenance, and function of neural circuits under physiological and pathological conditions, using both Drosophila and mammalian models.

Dr. Spergel focuses on translational research in IgE-mediated and non-IgE-mediated food allergy, examining novel clinical methods for desensitization and curing food allergy. His other main projects are to identify predictive factors for severity of reactions using molecular, physiologic, and clinical parameters.

Dr. Spinner's research focuses on the etiology and expressivity of pediatric developmental disorders. She uses genomic methods to focus on the multisystem disorder Alagille syndrome and biliary atresia, a likely heterogeneous and poorly understood condition. She is also interested in using genomic tools to continue to improve diagnostic rates for constitutional genetic disorders.

Dr. Srinivasan's research focuses on robotic and laparoscopic surgery, as well as stone disease. His interests include techniques in minimally invasive surgery, tools in management of voiding dysfunction and neurogenic bladder, and design/development of diagnostic and therapeutic devices in urology.

Vijay Srinivasan, MBBS, MD, works in research and quality improvement programs dealing with critical illness endocrinopathies and nutrition to improve outcomes in critically ill children. His research focuses on stress hyperglycemia with tight glycemic control and nutrition therapy.

Dr. St. Geme's research focuses on bacterial pathogenesis, with an emphasis on defining the molecular and cellular determinants of Haemophilus influenzae and Kingella kingae disease.

Dr. Stachelek's research interests are in the cellular and molecular mechanisms that control vasculature inflammation.

Dr. Stallings is working on intervention trials involving three chronic diseases with nutrition-related abnormalities resulting in meaningful adverse outcomes: cystic fibrosis (new drugs), sickle cell disease (vitamin A) and chronic pancreatitis (enzyme replacement drug).