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Dr. O'Connor investigates the immunological aspects of heart transplantation in children, specifically the impact of anti-HLA antibodies. The presence of these antibodies can complicate or even prevent a transplant from happening; therefore, reducing or eliminating them before transplant is important for a patient to receive a heart that is compatible with his or her immune system.
Dr. Offit is director of the Vaccine Education Center at CHOP and an internationally recognized expert in the fields of virology and immunology. He is co-inventor of a landmark vaccine achievement for the prevention of rotavirus gastroenteritis.
Dr. Olson aims to improve diagnostics and treatment of bone marrow failure (BMF) syndromes, and to improve clinical hematopoietic stem cell transplantation (HSCT) outcomes. He conducts clinical trials of HSCT for non-malignant hematologic diseases. His laboratory explores both basic and translational research focused on genomics of BMF and the impact of BMF on hematopoietic niche function during HSCT.
Dr. Ortiz-Gonzalez is a physician-scientist specializing in pediatric neurogenetics. Her clinical work focuses on finding a unifying genetic diagnosis for children with rare neurodevelopmental disorders. Her research is informed by her patients and focuses on understanding how genetic changes, in particular those affecting mitochondrial function, cause disease so we can develop better treatments for these children in the future.
Dr. Osterhoudt is an attending physician in the Division of Emergency Medicine and the medical director of the Poison Control Center at Children's Hospital of Philadelphia. His interests include the clinical epidemiology and risk assessment of pediatric poisoning exposures, and infantile methemoglobinemia.
Dr. O'Byrne is a pediatric cardiologist with research interests in cardiac disease outcomes, perioperative outcomes, and children with pulmonary hypertension. He combines the use of large observational datasets to study outcomes, practice variation, cost, and the determinants of health-related quality of life in this population.