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Dr. Eisch is a neuroscientist interested in how molecular, cellular, and circuit changes—particularly in the limbic system—influence motivated behavior and cognition. She is specifically interested in how neuroplasticity in the hippocampal dentate gyrus contributes to both normal and pathological function with relevance to depression and addiction.
Dr. Emanuel investigates diseases caused by abnormalities of human chromosome 22. These include the most common microdeletion syndrome, 22q11.2 deletion syndrome, and the most common recurrent constitutional translocation in humans, the t(11;22). Her efforts include discerning the mechanisms involved in generating the deletion and translocation as well as looking for modifiers of the phenotype in individuals with the deletion syndrome.