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Dr. Camire's research focuses on understanding the components of the blood coagulation system, how they interface with activated cells, and how disturbances in their function lead to bleeding and thrombosis. He is also interested in developing novel therapeutic approaches (protein, gene-based, small molecule) to mitigate these events, which are major causes of morbidity and mortality worldwide.
Dr. Cardinale's research is focused on understanding the mechanisms of gene expression and gene regulation in autoimmune diseases, including inflammatory bowel disease, type 1 diabetes, and systemic sclerosis. He uses data from large-scale genomic studies to identify disease-causing genetic variants and functionally explore the target genes of those variants.
Dr. Chang is a clinical investigator focusing on cardiovascular assessment and outcomes of pediatric-onset systemic lupus erythematosus (pSLE). Her research assesses the utility of various screening modalities, including echocardiography, ambulatory blood pressure monitoring, and tonometry, for the early detection of cardiovascular disease. Her research goals are to develop screening protocols and targeted interventions to prevent pSLE-related cardiovascular morbidity and mortality.
Dr. Choi's research focuses on the role of RNA-binding proteins in the regulation of alternative splicing and how mutations in these factors contribute to cancer. He uses a combination of genetically-engineered models and high-throughput approaches to better understand how alternative splicing influences cellular function and to identify potential opportunities for therapeutic intervention.
Dr. Chorny's research program focuses on nanomedicines as well as drug, cell, and gene delivery systems for treating proliferative disease. His current research specifically focuses on the use of nanoparticle-mediated delivery to solid tumors and site-specific delivery for cardiovascular disease.
Dr. Cielo conducted clinical and translational research related to the mechanisms and effects of obstructive sleep apnea in children, with a specific focus on infant populations, children with craniofacial conditions, and the use of MRI and other imaging modalities to understand structural contributors to obstructive sleep apnea in children.
Dr. Coffin’s research interests focus on the epidemiology and prevention of healthcare-associated infections in the pediatric population. She also investigates the epidemiology of pediatric respiratory viral infections, with a particular emphasis on influenza.
Dr. Cole is a pediatric neuro-oncologist who has dedicated her career to translational and clinical research, combining her expertise in molecular pathology, cancer genomics, and developmental therapeutics to identify novel treatments for children with cancer.
Dr. Conine works to understand the functions of small RNAs in reproduction, epigenetic inheritance, and development. His research focuses on how small RNAs in sperm transmit epigenetic information to offspring, as well as their involvement in male fertility.
Dr. Connolly coordinates CHOP's participation in the electronic Medical Records and Genomics (eMERGE) Consortium, a major NHGRI-funded initiative to integrate health records and genomics. He also has led a range of neuropsychiatric studies and trained as neuropsychologist at Trinity College Dublin.
Dr. Corwin’s research focuses on pediatric concussion. He has a particular interest in improving the diagnosis and initial management of pediatric concussion, specifically using specialized examination techniques to identify shortly following the injury those children at highest risk for a prolonged recovery, as well as ways to maximize the diagnostic accuracy from the Emergency Department.
Dr. Coulter conducts physiological studies examining mechanisms of epilepsy. His research centers on injury-induced epilepsies as well as genetically-induced epilepsy, autism, and developmental intellectual disabilities.
Dr. Curley's research focuses on nurse-implemented interventions in pediatric critical care. Over several decades, her studies have illuminated relationship-based care when partnering with parents of critically ill children, supported parent presence during invasive procedures and resuscitation, and have informed the practice of caring for critically-ill pediatric patients with acute respiratory failure.