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Dr. Ackermann studies diabetes (types 1 and 2) and congenital hyperinsulinism using mouse models, cell lines, and primary human tissue. She aims to identify novel pathways regulating beta cell insulin secretion, leading to innovative therapeutic strategies for these disorders. Current studies include in vivo mouse physiology, ex vivo human islet physiology, CRISPR-Cas9 gene editing, epigenetic modification, and single-cell functional genomics.
Dr. Adamson serves as chair of the international consortium Children's Oncology Group and on the National Cancer Advisory Board. In addition to his national and international leadership roles in pediatric oncology, Dr. Adamson maintains a dynamic research program on pediatric clinical-translational drug development, with a strong focus on childhood cancer drug development.
Dr. Ahrens-Nicklas works to understand why patients with inherited biochemical disorders often suffer severe, untreatable neurologic and cardiac symptoms. She strives to elucidate the link between biochemistry and network excitability, in order to drive new approaches to therapy.
Dr. Akers is an adolescent gynecologist and her research focuses on improving reproductive health outcomes among adolescent women by reducing teen pregnancy, and reducing sexually transmitted infection rates by increasing adolescents’ access to high quality reproductive health services.
The research interests of Dr. Allen include lung function testing in children, adolescents, and infants; developmental chest wall physiology; pulmonary complications of sickle cell disease; and complications of cystic fibrosis.
Dr. Amaral's research is focused on kidney transplantation with particular interests in reducing treatment burden for adolescents and young adults — from designing studies to make daily medication regimens easier to diagnosing transplant injury earlier using innovative, noninvasive approaches.
As a bioengineer, Dr. Arbogast's research focuses on pediatric injury biomechanics, injury causation and the effectiveness of safety products for children with a concentration in the safety of children and youth in motor vehicle crashes as well as pediatric concussion.
The development of gene-based strategies for the treatment of bleeding and thrombotic diseases is at the heart of research by Dr. Arruda. Working collaboratively, Dr. Arruda and his colleagues have carried out early-phase clinical studies on adeno-associated viral vectors for the treatment of severe hemophilia B.