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Dr. Pacifici's biomedical research spans three decades and has explored mechanisms of skeletal development and growth in fetal and postnatal life. Specifically, his focus has been on identifying the cellular and molecular mechanisms that regulate the differentiation of progenitor cells and permit assembly of distinct skeletal structures, and on aberrations of these mechanisms in pediatric skeletal disorders.
Dr. Pasha studies the mechanism of spinal deformity development in the pediatric population. She uses analytical and computational methods to better understand the pathogenesis of pediatric scoliosis. Her lab develops medical devices and software packages that can be used in orthopedic clinics worldwide.