In This Section
Dr. Monos is an internationally recognized expert on histocompatibility (HLA) molecules. His work covers a wide spectrum of HLA-related issues that pertain to both the molecular (structure/function) aspects of HLAs, as well as the genetics of the major histocompatibility complex, that includes the genes encoding the HLA molecules.
Dr. Monos' research interests cover a wide spectrum of HLA-related topics. His lab, in conjunction with other laboratories, has pioneered the DNA-based methodologies for HLA typing. He has worked on a number of structure/function relationships of HLAs, which are very important for the immune response, and he has identified associations of HLAs with several diseases, including Type 1 diabetes, pemphigus vulgaris, tuberculoid leprosy, berylliosis, sarcoidosis, Guillain Barre Syndrome, ovarian carcinoma, and Crohn's disease.
His work also has contributed to the development of the key concept that the strong linkage disequilibrium observed within the major histocompatibility complex (MHC) does not simply reflect the significance of several genes within this genomic region for the physiological functioning of the immune system, but also for the observed disease associations with the HLAs. Genes within the MHC, in coordination or independently of particular HLA alleles, generate the disease phenotype. The realization that there are additional genes besides HLAs within the MHC for predisposing to disease susceptibility has been the guiding principle for the recent intense efforts to fully characterize this genomic region and investigate disease associations with a dense set of SNPs.
Dr. Monos also collaborates with the Stem Cell Transplant team and the Nephrology, Cardiology, and Gastroenterology divisions at CHOP. He performs research on a number of clinically related projects where support from the Immunogenetics lab is necessary.
Education and Training
BS, University of Patras, Greece (Biology), 1975
PhD, Georgetown University (Biochemistry/Immunology), 1981
Fellowship, University of Pennsylvania (Immunopathology), 1986
Titles and Academic Titles
Director, Immunogenetics Laboratory
Professor of Pathology and Laboratory Medicine
American Association of Immunologists, 1984-
American Society for Histocompatibility and Immunogenetics, 1985-
Academy of Clinical Laboratory Physicians and Scientists, 1993-
American Society for Histocompatibility and Immunogenetics Scholar Award, 2010, 2015, 2016
American Society for Histocompatibility and Immunogenetics Distinguished Scientist Award, 2017