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Contact
E-mail
monosd [at] email.chop.edu
Phone
Location - People View
Room 707A

3615 Civic Center Blvd
Philadelphia, PA 19104
United States

Research Topics
Dimitrios S. Monos, PhD
Dimitrios S. Monos
Director, Immunogenetics Laboratory

Dr. Monos is an internationally recognized expert on histocompatibility (HLA) molecules. His work covers a wide spectrum of HLA-related issues that pertain to both the molecular (structure/function) aspects of HLAs, as well as the genetics of the major histocompatibility complex, that includes the genes encoding the HLA molecules.

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Bio

Dr. Monos' research interests cover a wide spectrum of HLA-related topics. His lab, in conjunction with other laboratories, has pioneered the DNA-based methodologies for HLA typing. He has worked on a number of structure/function relationships of HLAs, which are very important for the immune response, and he has identified associations of HLAs with several diseases, including Type 1 diabetes, pemphigus vulgaris, tuberculoid leprosy, berylliosis, sarcoidosis, Guillain Barre Syndrome, ovarian carcinoma, and Crohn's disease.

His work also has contributed to the development of the key concept that the strong linkage disequilibrium observed within the major histocompatibility complex (MHC) does not simply reflect the significance of several genes within this genomic region for the physiological functioning of the immune system, but also for the observed disease associations with the HLAs. Genes within the MHC, in coordination or independently of particular HLA alleles, generate the disease phenotype. The realization that there are additional genes besides HLAs within the MHC for predisposing to disease susceptibility has been the guiding principle for the recent intense efforts to fully characterize this genomic region and investigate disease associations with a dense set of SNPs.

Dr. Monos also collaborates with the Stem Cell Transplant team and the Nephrology, Cardiology, and Gastroenterology divisions at CHOP. He performs research on a number of clinically related projects where support from the Immunogenetics lab is necessary.

Education and Training

BS, University of Patras, Greece (Biology), 1975

PhD, Georgetown University (Biochemistry/Immunology), 1981

Fellowship, University of Pennsylvania (Immunopathology), 1986

 

Titles and Academic Titles

Director, Immunogenetics Laboratory

Professor of Pathology and Laboratory Medicine

Professional Memberships

American Association of Immunologists, 1984-

American Society for Histocompatibility and Immunogenetics, 1985-

Academy of Clinical Laboratory Physicians and Scientists, 1993-

Professional Awards

American Society for Histocompatibility and Immunogenetics Scholar Award, 2010, 2015, 2016

American Society for Histocompatibility and Immunogenetics Distinguished Scientist Award, 2017

 

Publication Highlights