In This Section
As director of the Center for Clinical Pharmacology, Dr. Zuppa has a dynamic research program that focuses on using clinical pharmacological modeling and simulation strategies to study the impact of critical illness on drug disposition in children.
Dr. Zuppa leads the Center for Clinical Pharmacology, which was established in 2014 to speed research from the bench to the bedside and emphasizes a single, consolidated resource for Children's Hospital of Philadelphia investigators interested in pharmacologic endeavors.
Her personal research efforts involve investigating the impact of critical illness on drug disposition in critically ill children.
The early stages of Dr. Zuppa's career in clinical pharmacology focused on drug utilization in the care of critically ill children. The purpose of this research was to identify the medications that were used in the care of critically ill children, yet lacked pediatric dosing guidance and/or dosing guidance in the setting of critical illness. Much of this work outlined the landscape of drug utilization in pediatric critical illness and identified candidate medications for clinical pharmacologic inquiry for her future studies.
She next focused her research efforts on further understanding drug disposition of drugs frequently used in this vulnerable population. Much of this work positively impacted clinical practice, and improved prescribing practices to make drug delivery safer and more effective.
In addition, Dr. Zuppa's research efforts have included improving drug delivery to children with congenital heart disease; working closely with the Collaborative Pediatric Critical Care Research Network on the pharmacoepidemiology of critical asthma; and improving drug prescribing practices for children undergoing surgery, specifically reducing the incidence of surgical site infections (SSIs) and reducing perioperative bleeding.
Education and Training
BS, Colgate University (Chemistry), 1992
MD, SUNY at Stony Brook, 1996
Fellowship, Children's Hospital of Philadelphia (Critical Care), 1999
MSCE, University of Pennsylvania (Epidemiology), 2004
Titles and Academic Titles
Director, Center for Clinical Pharmacology
Associate Director of PICU Fellowship Program
Associate Professor of Anesthesiology and Critical Care
Society of Critical Care Medicine, 1998-
American Academy of Pediatrics, 1998-
American College Of Clinical Pharmacology, 2004-
American Society of Clinical Pharmacology and Therapeutics, 2006-
Fellow, American Academy of Pediatrics, 2003
Junior Clinical Investigator Award — CHOP General Clinical Research Center, 2003
Residency Teaching Award from CHOP, 2004
Fellow, American College of Clinical Pharmacology, 2006