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In This Section
Dr. Muir investigates the mechanisms underlying esophageal fibrosis to improve therapeutic and diagnostic approaches.
The aim of Dr. Muir's research program is to improve the lives of children with eosinophilic esophagitis (EoE) and prevent the devastating consequences of esophageal inflammation and subsequent fibrosis. Among its many complications, esophageal fibrosis is the most striking complication of EoE, predisposing subjects to recurrent food impactions, emergent endoscopy, impaired esophageal motility, and esophageal stricture.
Dr. Muir works to develop novel approaches to detect and treat fibrosis and inflammation in the esophagus. Her studies emphasize the dynamic interplay between the epithelium and fibroblasts in order to pursue a detailed understanding of homeostatic signaling mechanisms in esophageal mucosa. Her lab uses 3D in vitro models and in vivo models of allergic disease, in addition to heavily utilizing patient-derived biopsies and serum specimens.
In addition, Dr. Muir has ongoing clinical/translational studies evaluating esophageal remodeling. Along with her lab team, she employs a technique that uses high-resolution impedance palimetry (EndoFLIP) to determine the distensibility of the esophagus and better appreciate ongoing esophageal remodeling. Her current studies seek to better understand the natural history of EoE during the maturation process and the effects of long-term disease activity in pediatric EoE.
Education and Training
BA, Amherst College, 2001
MD, UMDNJ - Robert Wood Johnson Medical School, 2007
Fellowship, Children's Hospital of Philadelphia (Gastroenterology, Hepatology and Nutrition)
Titles and Academic Titles
Assistant Professor of Pediatrics
American Gastroenterology Association, 2010-
North American Society for Pediatric Gastroenterology, Hepatology and Nutrition, 2010-
American Gastroenterological Association Clinical Skills Travel Award, 2012
American Gastroenterological Association Fellow Abstract Prize, 2014
Komarov Research Competition - 3rd place, 2014
Fellowship2Leadership Salix Travel Grant, 2014
American Partnership for Eosinophilic Disorders North American Society for Pediatric Gastroenterology, Hepatology and Nutrition Award for Basic Science Abstract, 2015